REGULATING GLIAL PROLIFERATION IN THE RETINA

描述（改编自申请人的摘要）：本申请侧重于 CD 81在视网膜细胞损伤反应中的作用。这 第一个证明CD 81在视网膜中表达， 损伤后基因产物有显著的上调。 假设TAPA是介导接触的分子复合物的一部分 抑制神经胶质细胞和视网膜色素上皮细胞（RPE）。这 申请将解决四个问题，关于CD 81和增殖 视网膜细胞的反应：（1）CD 81是否调节胶质细胞和RPE数量 在正常视网膜发育过程中;（2）CD 81是否在以下过程中发挥作用 （3）CD 81的活化是否下调了细胞增殖， 视网膜神经胶质细胞的反应;（4）与CD 81相关的神经胶质蛋白， 调节视网膜细胞增殖。

DESCRIPTION (Adapted from the applicant's abstract): This application focuses on the role of CD81 in the cellular response of the retina to injury. This group was the first to demonstrate that CD81 is expressed in the retina and that there is a significant up-regulation of the gene product following injury. The hypotheses is that TAPA is part of the molecular complex mediating contact inhibition for glial cells and retinal pigment epithelium (RPE). This application will address four questions regarding CD81 and the proliferative response of retinal cells: (1) whether CD81 regulates glial cell and RPE number during normal retinal development; (2) whether CD81 plays a role following injury; (3) whether the activation of CD81 down-regulates the proliferative response of retinal glia; and (4) what glial proteins associate with CD81 to regulate cell proliferation in the retina.