Dynamic trafficking of amino acid transporters at synapses and their role in regulating neurotransmission

脑细胞释放化学神经递质来激活它们的邻居。最丰富的神经递质是谷氨酸，它介导了大脑中的大部分通信。释放后，这种神经递质必须迅速回收，以防止水平被耗尽和神经传递失败。这项资助的主题是了解什么分子和途径用于回收大脑中的谷氨酸，以及如何控制其供应以维持持续的大脑激活。

Brain cells release chemical neurotransmitters to activate their neighbours. The most abundant neurotransmitter is glutamate, which mediates most of the communication in the brain. Following release, this neurotransmitter must be rapidly recycled to prevent levels being depleted and neurotransmission failing. The subject of this grant is to understand what molecules and pathways are used to recycle glutamate in the brain, and how its supply is controlled to sustain continual brain activation.