ATHEROSCLEROSIS AND RISK OF AGE-RELATED MACULOPATHY

描述：(申请人摘要)这项流行病学研究的目的是 目的：评估泛发性动脉粥样硬化的标志物与 老年性黄斑病变早期和晚期的发病率 以人群为基础的嵌套事件病例对照研究。这项建议的基础是 威斯康星州海狸水坝人口老龄化研究：海狸水坝之眼 研究(EY06594)和听力损失流行病学研究(AG11099)。 患有早期老年性黄斑病变或晚期黄斑病变的参与者 根据标准化照片的分级确定的老年性黄斑病变 在相隔五年的两次考试中参加的考试将有资格成为本次考试的案例 学习。10岁时无年龄相关性黄斑病变的参与者 后续的眼睛检查将符合条件作为对照。突发事件早期案例 将按年龄和性别与对照组进行频率匹配，比例为2：1 对照与病例的比率。晚发老年性黄斑病变病例将 按年龄和性别与对照组进行频率匹配，比例为3：1 对案例的控制。基于预期的5年发病率和参与率 在这两项研究中，我们估计总共有189例 早期老年性黄斑病变与378例对照组和34例晚期发病病例 老年性黄斑病变和102名对照将纳入这项研究。 全身性动脉粥样硬化将通过内膜-中层厚度和 颈动脉内有斑块。存储的B模式录像带 从流行病学开始，我们得到了颈动脉的超声扫描结果。 在听力损失研究中，使用了动脉粥样硬化风险的修改 社区学习协议。这些扫描将被读取，并测量 使用社区动脉粥样硬化风险测量的动脉内膜-中层厚度 超声波读数协议。 众所周知，老年性黄斑病变是导致失明的主要原因。 对老年人来说，这是一个重大的公共卫生问题。AS 然而，没有办法预防或有效治疗这种疾病。本研究 将提供重要的流行病学信息，说明 老年性黄斑病变病因中的动脉粥样硬化。它利用了 一个独特的机会，通过利用现有的 以人群为基础的队列和标准化的发病率评估 老年性黄斑病变和标准化的颈动脉超声扫描。

DESCRIPTION: (Applicant's Abstract) The purpose of this epidemiologic study is to evaluate the association of markers of generalized atherosclerosis with the incidence of early and late stage age-related maculopathy in a population-based, nested incident case-control study. This proposal builds on the population-based studies of aging in Beaver Dam, WI: The Beaver Dam Eye Study (EY06594) and the Epidemiology of Hearing Loss Study (AG11099). Participants with incident early age-related maculopathy or incident late-stage age-related maculopathy as determined from grading of standardized photographs taken at two examinations five years apart will be eligible as cases for this study. Participants without age-related maculopathy at the time of the 1 0-yr follow-up eye examination will be eligible as controls. Incident early cases will be frequency-matched by age and gender to controls using a two-to-one ratio of controls to cases. Incident late age-related maculopathy cases will be frequency-matched to controls by age and gender using a three-to-one ratio of controls to cases. Based on expected 5-yr incidence rates and participation rates in both studies, we estimate that a total of 189 cases with incident early age-related maculopathy and 378 controls and 34 cases with incident late age-related maculopathy and 102 controls will be included in this study. Generalized atherosclerosis will be measured by intima-medial thickness and the presence of plaque in the carotid arteries. Stored videotapes of B mode ultrasound scans of the carotid arteries were obtained as of the Epidemiology of Hearing Loss Study, using a modification of the Atherosclerosis Risk in Communities Study protocol. These scans will be read, and measurements of the intima-medial thickness made, using the Atherosclerosis Risk in Communities ultrasound reading protocol. Age-related maculopathy is well-recognized to be the leading cause of blindness among older adults and a significant public health problem for older adults. As yet there is no way to prevent or effectively treat this disorder. This study will provide important epidemiologic information about the role of atherosclerosis in the etiology of age-related maculopathy. It takes advantage of an unique opportunity to evaluate this association by utilizing an existing population-based cohort with standardized assessments of the incidence of age-related maculopathy and standardized carotid artery ultrasound scans.