Dynamics and mechanisms of immune complex-mediated skin inflammation

III型超敏反应是许多常见自身免疫性疾病的基础，包括类风湿性关节炎和红斑狼疮。这些疾病是由免疫复合物（IC）的沉积和中性粒细胞在小血管内的积累引起的。我们将使用实时成像技术在空间和时间上解剖III型超敏反应中中性粒细胞的募集和IC沉积，以便更好地了解这些疾病的发病机制。

Type III hypersensitivity underlies a number of common autoimmune diseases, including rheumatoid arthritis and lupus erythematosus. These diseases are caused by the deposition of immune complexes (IC) and the accumulation of neutrophils within small blood vessels. We will use real time imaging to dissect in space and time the recruitment of neutrophils and IC deposition during type III hypersensitivity reactions in order to better understand the pathogenesis of these conditions.