Analysis of Sex Hormones and Lipoproteins in Young Males

描述 (由申请人提供)此申请请求支持 青春期男性性激素和脂蛋白的分析研究 (HD/HL18281)，一项为期3年(1984-1987)的血脂、血压、体重、 青春期男性的脂肪模式和性类固醇激素(SSH)。总计 在664名10-15岁的黑人和白人男性中，他们参加了一项设计的研究 作为年龄队列中两年多的一系列重复数据收集。 横断面分析被用来解释在 青春期SSH及黑人和白人男孩SSH与血脂的关系 以及有和没有冠心病家族史的男孩之间的差异。当数据被 最初为本研究收集的灵活的理论模型 纵向分析技术已经开发出来，但还不能使用。 供电脑使用。这些技术现在由软件支持，允许更多 对这些数据进行强大而完整的分析。 这些分析的主要目的是阐明变化的贡献 在SSH和脂肪模型中对血浆高密度脂蛋白(HDLc)浓度的变化 和低密度脂蛋白胆固醇、甘油三酯和 载脂蛋白(Apo)：男性在青春期出现的载脂蛋白A1、ALL和B。宋承宪 测定雌二醇(E_2)和游离睾酮(T)。我们将测试 以下假设：(1)增加自由T预测/导致减少 青少年高密度脂蛋白胆固醇与低密度脂蛋白、载脂蛋白B及低密度脂蛋白/高密度脂蛋白比值的关系 (2)增加E2预示载脂蛋白B、低密度脂蛋白-C和低密度脂蛋白-C/高密度脂蛋白- C比率，但由此产生的影响将因肥胖和脂肪而不同 (3)快速的体重增加预示着中心性肥胖的增加， 定义为躯干皮褶与总皮褶的比率， 高密度脂蛋白胆固醇降低，甘油三酯、载脂蛋白B、低密度脂蛋白胆固醇和低密度脂蛋白升高。 C/高密度脂蛋白胆固醇比值。体重的快速增加预示着雌二醇的增加，但导致动脉粥样硬化的 中心性肥胖增加对血脂的影响大于抗肥胖 雌二醇的致动脉粥样硬化作用。 这些分析将提供对代谢因素的更好的理解 潜在的肥胖-激素-脂蛋白关系。鉴于这口井- 有记录的美国青年肥胖率上升，这些分析是 特别是切合实际并解决重要的公共卫生问题。

DESCRIPTION (Provided by Applicant) This application requests support for secondary analysis of the Sex Hormones and Lipoproteins in Adolescent Males Study (HD/HL18281), a 3-year (1984-1987) study of lipids, blood pressure, weight, fat patterning, and sex steroid hormones (SSH) in adolescent males. A total of 664 black and white males, ages 10-15, were enrolled into a study designed as a series of repeated data collections over 2 years within age cohorts. Cross-sectional analyses have been used to explain differences during adolescence in SSH and SSH-lipid relationships between black and white boys and between boys with and without a family history of CHD. When the data were originally collected for this study, theoretical models of flexible longitudinal analytic techniques had been developed, but were not available for computer use. These techniques, now supported by software, allow a more powerful and complete analysis of these data. The primary aim of these analyses is to explicate the contribution of changes in SSH and fat patterning to changes in plasma concentrations of high (HDL-C) and low (LDL-C) density lipoprotein cholesterol, triglycerides (TG), and apolipoproteins (apo) Al, All, and B occurring during puberty in males. SSH assayed included estradiol (E2) and free testosterone (T). We will test the following hypotheses: (1) increasing free T predicts/leads to decreases in HDL-C and increases in LDL-C, apo B, and the LDL-C/HDL-C ratio in adolescent males; (2) increasing E2 predicts decreases in apo B, LDL-C and the LDL-C/HDL- C ratio, but the resultant effects will vary with adiposity and fat patterning; (3) rapid weight gain predicts increased central adiposity, defined as the ratio of truncal skinfolds to total skinfolds, and with greater decreases in HDL-C and increases in triglycerides, apo B, LDL-C and the LDL- C/HDL-C ratio. Rapid weight gain predicts increased E2, but the atherogenic effects of increased central adiposity on lipids are greater than the anti- atherogenic effects of E2. These analyses will provide a better understanding of metabolic factors underlying obesity-hormone-lipoprotein relationships. Given the well- documented increase in obesity in American youth, these analyses are especially pertinent and address important public health issues.