Gamma Synchronization in Schizophrenia Spectrum Disorder

在伽马频率范围内（30赫兹或更高）的神经活动被假设为反映了与物体各种特征的结合或整合有关的神经集合的同步。伽马范围同步被认为依赖于抑制性gaba能回路，这与精神分裂症有关。该项目将研究听觉神经回路是否支持精神分裂症或分裂型人格障碍的伽马范围同步。精神分裂型人格障碍在遗传和症状上与SZ相关，但没有慢性精神病中存在的复杂变量，如长期药物治疗、住院治疗和生活方式的改变。通过将脑电图与不同频率的周期性听觉刺激相结合来评估伽玛范围的同步。由于伽马范围同步缺陷可能是多种信息处理障碍的基础，伽马范围同步缺陷、临床症状和智力表现之间的关系也将被评估。这些数据可以识别精神分裂症谱系障碍中振荡机制的干扰，并开发新的技术来非侵入性地探测脑功能障碍中的神经回路。

Neural activity in the gamma frequency range (30 Hz or greater) has been hypothesized to reflect the synchronization of neural assemblies involved in binding or integration of various features of an object. Gamma range synchronization is thought to depend on inhibitory GABAergic circuits, which have been implicated in schizophrenia. This project will investigate whether auditory neural circuits can support gamma range synchronization in schizophrenia, or in schizotypal personality disorder. Schizotypal personality disorder is genetically and symptomatically related to SZ, but without the complicating variables present in a chronic psychotic disorder, such as long-term medication, hospitalization, and lifestyle changes. Gamma range synchronization will be evaluated by entraining the electroencephalogram to different frequencies of periodic auditory stimulation. Since deficits in gamma range synchronization may underlie a variety of information processing disturbances, the relationship among gamma range synchronization deficits, clinical symptoms and intellectual performance will also be evaluated. These data may identify disturbances in oscillatory mechanisms in schizophrenia spectrum disorders, and develop novel techniques to non-invasively probe neural circuits in brain dysfunction.