TRENDS IN TRANS-FATTY ACID INTAKE BETWEEN 1980 AND 1997

描述 (改编自申请者的摘要)近年来引起了关注 关于美国人饮食中反式脂肪酸的潜在健康危害。 饮食中反式脂肪酸的摄入量与不健康的变化有关 血脂与冠心病(CHD)的关系 学习。尽管一些研究估计了反式脂肪酸的摄入量 在美国人口中，目前缺乏关于维生素C摄入量趋势的数据 人群中的反式脂肪酸。此外，目前还不清楚 反式脂肪酸的摄入可能与其他饮食和饮食的变化有关 非膳食冠心病危险因素与冠心病死亡率。 这项提议旨在利用新获得的营养数据来重新计算 作为明尼苏达州心脏调查(MHS)的一部分收集的饮食数据 反式脂肪酸的摄入量趋势。MHS是一项持续的观测 高危因素与心血管病发病趋势的流行病学研究 人群独立横断面概率样本的死亡率 明尼阿波利斯--圣彼得堡保罗，明尼苏达州，大都市区。调查在#年进行。 1980-1982年、1985-1987年、1990-1992年和1995-1997年。饮食是心血管疾病的危险因素之一 作为每个调查的一部分衡量的因素。在这项研究中，24小时饮食 从MHS参与者收集的召回将使用更新的 食物和营养数据库，包括反式脂肪酸的值(16：1，18：1， 18：2，总计)。重新计算得出的进食量估计数为 分析以检查1980年间反式脂肪酸摄入量的时间趋势 和1997年，并检查反式脂肪的时间趋势之间的关系 酸摄入量与其他饮食和非饮食冠心病风险的时间变化 冠心病死亡率的影响因素及变化。 MHS的数据提供了一个独特的机会来检查饮食成分 最近才被认为是冠心病的潜在危险因素。

DESCRIPTION (Adapted from the applicant's abstract) In recent years concern has arisen about the potential health hazards of trans-fatty acids in the American diet. Dietary intake of trans-fatty acids has been linked to unhealthy shifts in serum lipid profiles and to coronary heart disease (CHD) in a number of studies. Although several studies have estimated intakes of trans-fatty acids in U.S. populations, presently data is lacking regarding trends in intake of trans-fatty acids in the population. Furthermore, it is unclear how trends in intake of trans-fatty acids may be related to changes in other dietary and non-dietary CHD risk factors and CHD mortality. This proposal aims to utilize newly available nutrient data to recalculate dietary data collected as part of the Minnesota Heart Survey (MHS) to examine trends in intake of trans-fatty acids. The MHS is an ongoing observational epidemiologic study of trends in risk factors and cardiovascular morbidity and mortality among independent cross-sectional probability samples of the Minneapolis-St. Paul, Minnesota, metropolitan area. Surveys were conducted in 1980-1982, 1985-1987, 1990-1992 and 1995-1997. Diet was among the CVD risk factors measured as part of each survey. In this research, 24-hour dietary recalls collected from MHS participants will be recalculated using an updated food and nutrient database that includes trans-fatty acid values (16:1, 18:1, 18:2, and total). Intake estimates resulting from recalculation will be analyzed to examine temporal trends in trans-fatty acid intake between 1980 and 1997, and to examine the relationship of temporal trends in trans-fatty acid intake to temporal changes in other dietary and non-dietary CHD risk factors and changes in CHD mortality. The MHS data provide a unique opportunity to examine a dietary constituent only recently recognized as a potential risk factor for CHD.