New technologies for targeted delivery of anti-bacterial agents

在抗生素耐药性细菌盛行的环境下，迫切需要新的方法来控制传染病。该项目旨在创建一种基于碳水化合物的新型技术，用于选择性地将抗菌剂靶向特定的细菌物种，以便能够选择性地根除混合微生物种群中的病原体。根据学生的技能和兴趣，该项目将涉及化学，生物化学，纳米粒子生成和修饰以及体外微生物学研究的组合。还将探索具有潜在临床和商业相关性的模型肠道和模型生物体分析。这个多学科项目汇集了来自John Innes中心和Procarta Biosystems Ltd.的互补学术和工业专业知识。

In a climate of prevailing antibiotic resistant bacteria, there is a pressing need for new ways to control infectious disease. This project aims to create a novel carbohydrate-based technology for selectively targeting anti-bacterial agents to specific bacterial species, in order to enable the selective eradication of pathogens in mixed microbial populations. Depending on the skills and interests of the student, the project will involve a combination of chemistry, biochemistry, nanoparticle generation and modification, and in vitro microbiology studies. There will also be scope to explore model gut and model organism analyses of potential clinical and commercial relevance. This multidisciplinary project brings together complementary academic and industrial expertise from the John Innes Centre and Procarta Biosystems Ltd.