Characterization of Presynaptic Protein Nerve wracked

描述（由申请人提供）：在本提案中，我计划调查 果蝇NMJ突触终扣的形成和功能。的 突触前对突触分化的控制很差 明白这种分化的一个表现是 突触终扣几乎所有的突触都有突触终扣， 这些静脉曲张的形成以及它们的功能还没有被 实验性地解决。果蝇新基因的初步数据 nerve-wracked表明，这种基因专门控制的形成， 在NMJ的纽扣。我计划进一步描述这个基因， 研究突触终扣的形成和功能的试剂。

DESCRIPTION (provided by applicant): In this proposal I plan to investigate the formation and function of the synaptic bouton at the Drosophila NMJ. The control of the differentiation of the synapse presynaptically is poorly understood. One manifestation of this differentiation is the formation of the synaptic bouton. Synaptic boutons are found at nearly all synapses but the formation of these varicosities as well as their function has not been addressed experimentally. Preliminary data from the novel Drosophila gene nerve-wracked suggests that this gene specifically controls the formation of boutons at the NMJ. I plan to further characterize this gene and use this reagent to investigate the formation and function of synaptic boutons.