Phosphorus Bioisosteres of the Sulfonyl Group: New Chemical Space

磺酰基- so2 -经常出现在农用化学和药物活性成分中。这项合作提案将提供基于有机磷的这一重要官能团的生物等构模拟物，从而获得新的化学空间和知识产权机会。这将通过开发新的合成方法来实现，这些方法可以绕过有毒的PCl3和其他难以处理的卤代膦中间体的膦、膦酸盐和膦酸盐。该项目属于EPSRC的职权范围，具体涉及合成有机化学、化学生物学和生物化学领域的研究。

The sulfonyl group, -SO2-, is frequently represented in both agrochemical and pharmaceutical active ingredients. This collaborative proposal will deliver organophosphorus-based bioisosteric mimics of this important functional group giving access to new chemical space and IP opportunities. This will be achieved through the development of new synthesis methods for phosphines, phosphonates and phosphinates that by-pass toxic PCl3 and other difficult-to-handle halophosphine intermediates. The project falls within the EPSRC's remit, specifically involving research in the areas of Synthetic Organic Chemistry and Chemical Biology and Biological Chemistry.