EFFECTS OF CHRONIC OZONE EXPOSURE ON LUNG FUNCTION

描述：（改编自研究者摘要） 美国人口暴露于环境臭氧（O3）浓度， 与急性呼吸系统健康影响有关;然而， 长期暴露于这些物质对人类呼吸系统健康的影响， 环境浓度。非人灵长类动物长期接触高浓度 O3浓度与中央腺泡的病理变化有关， 与年轻香烟中观察到的变化相似的肺区域 吸烟者。根据调查人员完成的试点研究，目前 一项研究验证了一个假设，即人类有一种对 长期暴露于环境O3的量与测量值之间的关系 肺功能的变化，反映了人类的中央腺泡区域的变化， 肺（FEF 25 -75）;这种关系在更多的测量中没有观察到。 近端气道功能（FEV 1）。 加州大学伯克利分校的一年级学生，年龄在18-21岁之间，他们是加州大学伯克利分校的终身居民。 洛杉矶盆地（n=200，高O3）和旧金山弗朗西斯科湾区（n=100， 低O3）进行研究。环境O3的寿命暴露将通过以下方式进行估计： 由调查者开发的方法，将联合收割机问卷和环境 O3数据。将使用最大呼气流量-容量评估肺功能 曲线.学生将在4-6个月的低环境O3暴露后进行研究 以及暴露于夏季O3 2-3个月后立即进行。四十个学生 (20来自每个地区），他们在FEF 25 -75的上尾和下尾 分配将经历2次受控的O3暴露（季节性同上） 随后进行BAL/活检，以评价 炎症、损伤/修复和氧化剂诱导损伤/修复和FEF 25 -75。 回归将用于评价寿命期O3暴露之间的关系 和肺功能，调整既往和家族呼吸道史，过敏 病史、家庭特征、暴露于环境烟草烟雾以及 颗粒物空气污染和NO2。 这是第一个详细的流行病学研究的影响， 根据个人终生暴露估计值计算的空气污染物暴露量 和受控暴露数据。该研究测试了一种特定的毒理学模型， 与慢性呼吸道疾病有关的人类， 影响机制。

DESCRIPTION: (Adapted from the Investigator's Abstract) A large part of the U.S. population is exposed to ambient ozone (O3) concentrations that are associated with acute respiratory health effects; however, little is known about the effects on human respiratory health of long-term exposure to such ambient concentrations. Chronic exposure of non-human primates to high concentrations of O3 are associated with pathologic changes in the centriacinar region of the lung that are similar to changes observed in young cigarette smokers. Based on pilot studies completed by the investigators, the current study tests the hypothesis that, humans, there is an exposure-response relationship between the amount of chronic exposure to ambient O3 and measures of lung function that reflect changes in the centriacinar region of the human lung (FEF25-75); and this relationship is not seen with measures of more proximal airway function (FEV1). First-year UC Berkeley students, ages 18-21 yrs, who are lifelong residents of the Los Angles Basin (n=200, high O3) and the San Francisco Bay Area (n=100, low O3) will be studied. Lifetime exposure to ambient O3 will be estimated with methods developed by the investigators that combine questionnaire and ambient O3 data. Lung function will be assessed with maximum expiratory flow-volume curves. Students will be studied after 4-6 months of low ambient O3 exposure and immediately after 2-3 months of exposure to summertime O3. Forty students (20 from each area) who are at the upper and lower tails of the FEF25-75 distribution will undergo 2 controlled O3 exposures (seasonal as above) followed by BAL/biopsy to evaluate relationships between measures of inflammation, injury/repair and oxidant induce damage/repair and FEF25-75. Regression will be used to evaluate relationships between lifetime O3 exposure and lung function, adjusted for past and family respiratory history, allergy history, home characteristics, exposure to environmental tobacco smoke and particle air pollution and NO2. This is the first detailed epidemiologic study of the effects of chronic exposure to an air pollutant based on individual estimates of lifetime exposure and controlled exposure data. The study tests a specific toxicologic model in humans that has relevance for chronic respiratory disease and explores mechanisms of effects.