Optical SmartProbe development for Molecular Imaging of the Ex Vivo Perfused Human Lung

光学活检询问人类肺部的前景提供了改善临床试验、药物发现计划的稳健性，同时也提供了危重患者的结果。使用智能荧光探针的光学分子成像提供了一种安全且负担得起的技术，可以分析多种肺部病理和疾病。鉴于目前缺乏用于诊断影响肺部的慢性疾病的可行化学探针，该项目的目的是合成几种SmartProbe并验证其生物学效用。利用这些探针，我们将研究交替激活的巨噬细胞和上皮细胞的功能。

The prospect of an optical biopsy to interrogate the human lungs offers to improve the robustness of clinical trials, drug discovery programmes, while also outcomes for critically ill patients. Optical molecular imaging using smart fluorescent probes offers a safe and affordable technique that will allow analysis of multiple lung pathologies and diseases. Given the lack of current viable chemical probes for the diagnostics of chronic conditions affecting the lungs, the aim of this project is to synthesise several SmartProbes and validate their biological utility. With these probes we will investigate the function of alternatively activated macrophages and the epithelium.