CANCER IN CHILDREN

这项建议的长远目标是进一步改善 儿童癌症的治疗， 范德比尔特大学儿童医学院的研究人员 癌症小组（CCS）。 多学科的调查小组， 范德比尔特正在与其他类似的团队共享资源， 研究机构，以调查生物学，治疗和流行病学， 儿童癌症。 具体目标可以根据范德比尔特的贡献来概括 对集团的科学努力和行政领导的贡献。 这些 包括： 1. 通过参加针对特定疾病的战略小组， 研究优先事项，并制定新的治疗研究策略 急性淋巴细胞白血病（ALL），霍奇金病，神经母细胞瘤， 骨肉瘤和脑瘤。 2. 通过担任研究委员会主席， 调查处理的开发、实施、分析和报告 治疗急性淋巴细胞白血病、神经母细胞瘤和脑肿瘤。 3. 通过作为研究委员会成员的参与， 开展与ALL、霍奇金淋巴瘤（Hodgkin's） 疾病、星形细胞瘤和脑干肿瘤。 4. 在研究的开发和解释方面提供领导 评估治疗性痴呆的发展和神经心理学后遗症， 治疗ALL。 5. 通过委员会的参与，为发展和 研究药物分析。 6. 通过参与行政领导， 执行委员会、官员委员会和附属活动 指导委员会。 此外，研究人员将继续争取参与， 范德比尔特患者CCG研究方案，以促进 迅速进行和及时完成小组研究。

The long-range objective of this proposal is further improvement in the treatment of cancer in children through the participation of investigators at the Vanderbilt University School of Medicine in Children Cancer Group (CCS). The multi-disciplinary team of investigators from Vanderbilt are pooling resources with comparable teams from other institutions to investigate the biology, treatment, and epidemiology of the childhood cancers. Specific aims can be summarized in terms of Vanderbilt's contributions to the Group's scientific endeavors and administrative leadership. These include the following: 1. Through participation in disease-specific Strategy Groups, establish research priorities and develop new strategies for therapeutic studies of acute lymphocytic leukemia (ALL), Hodgkin's disease, neuroblastoma, bone sarcomas, and brain tumors. 2. Through Study Committee chairmanships, provide leadership in the development, conduct, analysis, and reporting of investigation dealing with the treatment of ALL, neuroblastoma, and brain tumors. 3. Through participation as Study Committee members, assist in the conduct of studies concerned with the treatment of ALL, Hodgkin's disease, astrocytoma, and brain stem tumors. 4. Provide leadership in the development and interpretation of studies that assess the developmental and neuropsychologic sequelae of curative therapy for ALL. 5. Through committee participation, contribute to the development and analyses of investigational drugs. 6. Provide administrative leadership through participation on the Executive Committee, the Officers Committee, and the Affiliate Activities Steering Committee. In addition, investigators will continue to enlist the participation of Vanderbilt patients in CCG research protocols so as to facilitate the expeditious conduct and timely conclusion of Group studies.