BEHAVIORAL, ERP AND EEG ASYMMETRY IN AFFECTIVE DISORDERS

描述（改编自申请人的摘要）：长期目标 是为了澄清异常知觉和电生理的性质， 情感障碍的不对称性，并评估大脑的价值 非对称性测量用于预测抗抑郁药治疗的结果。 具体目标是：1）评估三因素模型，其中症状 一般的负面情绪，焦虑唤醒和快感缺乏被假设为 与特定区域的大脑不对称有关; 2）比较不对称性 只有抑郁症，焦虑症， 或两者都有障碍; 3）测试焦虑唤醒是 与右侧顶颞激活相关; 4）评估预测的 快感缺乏和非快感缺乏的大脑区域不对称性的差异 抑郁症的亚组; 5）测试大样本的患者， 电生理测量，以评估预测的差异， 治疗反应和无反应之间的半球不对称性 分组。 将对总共200名未用药患者和40名正常对照进行测试， 一系列的行为偏侧性，静息脑电图， 和认知事件相关电位（ERP）的措施，在三项研究。 研究1使用2 × 2设计比较仅患有MDD的患者， 仅焦虑症（恐慌症或社交恐惧症）或两种疾病，并且正常 对照 受试者还接受皮肤电和心理测试 焦虑性唤起的指标 研究2比较了快感缺乏和 非快感型抑郁症是在自我报告的基础上形成的， 对愉快刺激的反应的评估，以及“基于访谈的” 诊断。 研究3比较了抗抑郁药应答者和无应答者， 行为和电生理测试，以及评估 快感缺失症 这些研究应有助于查明 抑郁症的亚型和特征性区域大脑不对称， 独特的临床特征。

DESCRIPTION (Adapted from applicant's abstract): The long range objectives are to clarify the nature of abnormal perceptual and electrophysiologic asymmetries in affective disorders, and to assess the value of brain asymmetry measures for predicting outcome of antidepressant treatment. Specific aims are: 1) to evaluate a three-factor model in which symptoms of general negative affect, anxious arousal and anhedonia are hypothesized to be related to specific regional brain asymmetries; 2) to compare asymmetries of patients having a depressive disorder alone, an anxiety disorder alone, or both disorders; 3) to test the prediction that anxious arousal is associated with right parietotemporal activation; 4) to evaluate predicted differences in regional brain asymmetries between anhedonic and nonanhedonic subgroups of depression; 5) to test a large sample of patients on electrophysiologic measures so as to evaluate predicted differences in hemispheric asymmetries between treatment responsive and nonresponsive subgroups. A total of 200 unmedicated patients and 40 normal controls will be tested on a battery of behavioral laterality, resting electroencephalography (EEG), and cognitive event-related potential (ERP) measures in three studies. Study 1 uses a 2 X 2 design to compare patients having a MDD only, an anxiety disorder only (panic or social phobia) or both disorders, and normal controls. Subjects are also tested on electrodermal and psychometric measures of anxious arousal. Study 2 compares subgroups of anhedonic and nonanhedonic depression formed on the basis of self-reports, structured assessments of responses to pleasurable stimuli, and "interview-based" diagnoses. Study 3 compares antidepressant responders and nonresponders on the behavioral and electrophysiologic tests, as well as on the assessments of anhedonia. These studies should contribute to the identification of subtypes of depression and characteristic regional brain asymmetries and distinctive clinical features.