HISTOPATHOLOGY CBF AND NMR ASSESSMENT OF STROKE

描述：(逐字摘自申请者的摘要)这项工作的主要目的 建议是调查血液动力学因素在多大程度上参与了 在以下情况下，与缺血相关的组织损伤增加 高血糖症。全身性血糖浓度升高一直是 与实验性中风后不良的神经结局有关 动物和人类。一些研究报告了脑血流量的变化 (CBF)与高血糖和CBF自我调节丧失相关 可能是导致不良结局的一个复杂因素 脑血管疾病中的高血糖。我们已经开发出一种新的高速 MRI技术连续监测脑血流量并已产生初步数据 这表明，在大鼠脑内，脑血流量急剧增加， D-葡萄糖输注伴随着一过性的自我调节丧失。这些 数据表明，血流动力学受损可能导致神经功能不佳。 与高血糖卒中相关的预后。这项工作将提高我们的 了解高血糖在中风中的作用可能有助于导致新的 卒中管理的方法。

DESCRIPTION: (Verbatim from the Applicant's Abstract) The main goal of this proposal is to investigate to what extent hemodynamic factors are involved in increased tissue damage associated with ischemia under conditions of hyperglycemia. Elevated systemic blood glucose concentrations have been implicated in poor neurological outcome following stroke in experimental animals and humans. Some studies have reported changes in cerebral blood flow (CBF) associated with hyperglycemia and loss of CBF autoregulation has been implicated as a possible complicating factor in poor outcome associated with hyperglycemia in cerebrovascular disease. We have developed a new high-speed MRI technique to monitor CBF continuously and have generated preliminary data which indicate that in rat brain there is an acute increase in CBF with D-glucose infusion with an associated transient loss of autoregulation. These data suggest that impaired hemodynamics may contribute to poor neurological outcome associated with hyperglycemia stroke. This work will improve our understanding of the role of hyperglycemia in stroke and may help lead to new approaches for stroke management.