STROKE M.I. AND ANTIPHOSPHOLIPID ANTIBODIES

描述：（改编自申请人的摘要）本发明的总体目标是： 项目是确定病理生理机制， 抗磷脂抗体（aPL）作为血管疾病的危险因素。的 假设aPL是缺血性卒中和心肌梗死预测因子 老年男性和女性的心肌梗死（MI），但与 动脉粥样硬化的进展。一项巢式病例对照研究被提议在 心血管健康研究（CHS）队列（5，201名男性和女性）和CHS 非裔美国人队列（687名男性和女性）。储存的冷冻基线血清和 心血管风险因素数据，包括止血措施和 炎症和内膜-中膜厚度（IMT）变化已经可用 所有研究参与者。研究人群均为65岁或以上， 基线，将包括370例缺血性卒中事件，370例 和1,480个种族匹配的对照组。为了允许分层， 种族在aPL分析中作为亚临床进展的预测因素 动脉粥样硬化，另外300人没有中风或心肌梗死史 将从非裔美国人中抽取样本血液也将被送往 德克萨斯大学圣安东尼奥分校进行最先进的aPL测定。 逻辑和线性回归模型将用于测试主要研究 假设这项研究的结果将证实aPL作为主要的 老年男性临床和亚临床血管疾病的危险因素， 并确定是否与血管疾病的关联是介导的 其他已知的风险因素。这些发现将是至关重要的设计， 未来的研究试图澄清免疫系统与 血管疾病

DESCRIPTION: (Adapted from Applicant's Abstract) The overall goal of this project is to define the pathophysiologic mechanism through which antiphospholipid antibodies (aPL) act as risk factors for vascular disease. The hypothesis is that aPL are predictors of ischemic stroke and myocardial infarction (MI) in elderly men and women, yet are not associated with progression of atherosclerosis. A nested case-control study is proposed within the Cardiovascular Health Study (CHS) cohort (5,201 men and women) and CHS African-American cohort (687 men and women). Stored frozen baseline sera and cardiovascular risk factor data including measures of hemostasis and inflammation and change in intimal-medial thickness (IMT) are already available on all study participants. The study population, all 65 years or older at baseline, will consist of 370 cases with incident ischemic stroke, 370 cases with incident MI, and 1,480 race-matched controls. To allow stratification by race in the analyses of aPL as predictors of progression of subclinical atherosclerosis, an additional 300 persons without a history of stroke or MI will be sampled from the African-American cohort. Blood will also be sent to the University of Texas at San Antonio for state-of-the-art aPL determinations. Logistic and linear regression models will be used to test major study hypotheses. The results of this study will confirm the role of aPL as major risk factors for clinical and subclinical vascular diseasse in elderly men and women and determine whether the association with vascular disease is mediated by other known risk factors. These findings will be vital in the design of future studies that seek to clarify the relationship of the immune system to vascular disease.