Computing a yeast Tree of Life

酵母是非常重要的生物，用于啤酒和面包制作，以及各种各样的生物工业。为了优化我们对国家酵母菌培养物（NCYC）中4000多个酵母菌株的开发，我们需要一个包含NCYC菌株的准确的酵母菌生命树。然而，目前还不存在这样的树。我们最近对大约600个NCYC菌株的基因组进行了测序。由此产生的数据集，可能是世界上最大的，将使我们能够比较目前的计算方法来开发这样的酵母生命树，并进一步开发新的基于下一代测序（NGS）的进化树重建方法。

Yeasts are hugely important organisms used in beer and bread making, in addition to a wide variety of bioindustries. To optimise our exploitation of the 4000+ yeast strains in the National Collection of Yeast Cultures (NCYC), we need an accurate yeast Tree of Life that encompasses the NCYC strains. However, no such tree is currently in existence. We have recently sequenced the genomes of approximately 600 NCYC strains. The resulting dataset, potentially the largest of its kind worldwide, will enable us to compare current computational approaches to developing such a yeast Tree of Life and to further develop new Next Generation Sequencing (NGS)-based approaches for evolutionary tree reconstruction.