2001 Gordon Research Conference on Bioenergetics

描述(申请人提供)：生物能量学戈登会议是 每两年召开一次，上一次于1999年6月举行。较大的(约500年 上周结束的欧洲生物能量学大会每隔一年举行一次。传统上，生物能量学GRC强调 关于电子传递和氧化磷酸化机制的讨论 随着对线粒体生物医学意义的讨论 肌病和衰老。然而，由于第一个高分辨率的大多数 通过能量传递获得了完整的膜蛋白结构 膜，本次会议已成为讨论以下问题的主要平台 整体膜蛋白生物化学。基于结构的机理探讨 涉及完整的膜蛋白现在已经成为一个基本主题 生物能量学GRC，以及在这一前沿领域的贡献是一个主要的 会议规划和组织方面的标准。因此， 上一年高分辨率(1.55A)结构的确定 细菌视紫红质，最高分辨率的膜蛋白结构，沿着 利用卤视紫质和视紫红质的高分辨率结构，创造了一个 这是比较介绍和讨论的绝佳机会 视紫红质家族的结构和进化。本方案还将 有关于主动运输和生物发生的主要会议。 戈登会议的非正式性和自发性的特点使得 深入讨论基本问题的可能性。为了进一步 在可行的范围内，推动此类讨论，使本会议 是围绕概念主题组织的，而不是专注于个人 蛋白质或实验系统。这是一个小小的实验，但我相信 这会很有趣的。 本申请所需资金的主要用途是支持 出席这次会议的有年轻人、研究生和 博士后。今年共有145名学生和博士后，其中46人 出席，来到了上届大会。研究发现，与 光谱分析方法和膜整体蛋白的定量分析 使教育和告知感兴趣的年轻研究人员成为必要 这个领域，谁将形成它的下一代。生物能量学GRC是 对于这些目的来说，这是一个极具灵感的场所。当然，这些想法和 年轻人贡献的研究对其他人也是鼓舞人心的 我们。

DESCRIPTION (provided by applicant): The Bioenergetics Gordon Conference is convened biannually and was last held in June, 1999. The larger (ca. 500 person) European Bioenergetics Congress, completed last week, is held in the alternate years. Traditionally, the Bioenergetics GRC has emphasized discussions on mechanisms of electron transport and oxidative phosphorylation, along with the discussions of the biomedical implications for mitochondrial myopathies and aging. However, as the majority of the first high resolution structures of integral membrane proteins were obtained from energy-transducing membranes, this Conference has become a major platform for discussions of integral membrane protein biochemistry. Structure-based discussion of mechanism involving integral membrane proteins has now become a basic theme of the Bioenergetics GRC, and contributions in this cutting-edge area are a major criteria in the planning and organization of the sessions. Thus, the determination in the last year of the high resolution (1.55 A) structure of bacteriorhodopsin, the highest resolution membrane protein structure, along with high resolution structures of halorhodopsin and rhodopsin, created a wonderful opportunity for a comparative presentation and discussion of the structures and evolution of the rhodopsin family. The present program will also have major sessions on Active Transport and Biogenesis. The special features of informality and spontaneity of Gordon Conferences allow the possibility of in-depth discussions of fundamental questions. To further stimulate such discussions, to the extent that it is feasible, this Conference is being organized around conceptual themes rather than focused on individual proteins or experimental systems. This is a bit of an experiment, but I believe it will be interesting. The major use of the funds requested in this application is to support the attendance at this conference of "young" people, graduate students and postdoctorals. Forty-six students and postdocs, out of a total of 145 in attendance, came to the last Conference. The research discoveries, relevance of spectoscopic methods, and quantitative analysis of integral membrane proteins make it essential to educate, and inform the young researchers interested in this field, who will form its next generation. The Bioenergetics GRC is a wonderfully inspiring venue for these purposes. Of course, the ideas and studies contributed by the younger folks are also inspirational to the rest of us.