CONFERENCE ON CONTROL OF VIRAL LATENCY AND PERSISTENCE

描述：几个病毒家族的成员（例如腺病毒， 细小病毒，乳头瘤病毒，乳多空病毒，疱疹病毒，逆转录病毒， 等等）。主要但不完全是通过建立 持续或潜伏感染。在潜伏感染的过程中， 基因组保持游离状态或整合到细胞中， 染色体，但保留复制能力，并导致显着 发病率。近年来，基于 蛋白质-蛋白质相互作用、基因组学、DNA阵列等具有显著的 推进了我们对病毒感染机制多样性的理解， 建立延迟。在许多关键发现中， 参与潜伏期和再激活建立的细胞功能 潜伏状态。同样重要的是目前对抑制 重新激活和故意重新激活潜伏病毒的存在， 抗病毒药物。延迟是一个常见的，但很小的组成部分， 和全国性的病毒学会议。病毒学会议的分裂 进入许多基于病毒家族的研讨会，有时只有基本的 科学或临床组成部分，同时大量扩散， 发表病毒学通讯的期刊已经排除了有意义的 年轻和更成熟的科学家之间的相互作用， 潜伏期方面或不同病毒家族中的工作者之间。近几 多年来，一直没有科学会议完全致力于病毒潜伏期， 持久性和延迟控制。这个新的Keystone的目的是 会议是汇集目前进入科学（研究生 和博士后培训生），主要研究人员和新工作者， 病毒持久性的基本方面以及为控制和 最终消灭潜伏的病毒我们希望会议将有一个 对未来研究产生开创性的影响，并吸引新一代的 科学家在这个领域。

DESCRIPTION: Members of several families of viruses (e.g. adenovirus, parvoviruses, papillomaviruses, papovaviruses, herpesviruses, retroviruses, etc.) persist in human cells principally but not exclusively by establishing persistent or latent infections. In the course of latent infections, viral genomes are retained in an episomal state or become integrated into cellular chromosomes but retain the capacity to replicate and to cause significant morbidity. In recent years the application of novel tools based on protein-protein interactions, genomics, DNA arrays, etc. have significantly advanced our understanding of the diversity of mechanisms by which viruses establish latency. Among many key findings are identification of viral and cellular functions involved in the establishment of latency and reactivation from latent state. Equally important is the current research on suppression of reactivation and on deliberate reactivation of latent viruses in the presence of antiviral drugs. Latency is a frequent but small component of international and national meetings in virology. The splintering of meetings in virology into numerous workshops based on virus families, sometimes with only basic science or clinical components, concurrent with a huge proliferation of journals publishing virological communications has precluded meaningful interaction among younger and more established scientists in the various aspects of latency or between workers in diverse virus families. In recent years there has been no scientific meeting totally dedicated to viral latency, persistence, and control of latency. The intent of this new Keystone conference is to bring together current entrants to science (graduate students and postdoctoral trainees), key investigators, and newcomers working on fundamental aspects of viral persistence and on the efforts to control and ultimately eradicate latent viruses. We hope that the meeting will have a seminal impact on future research as well as attract a new generation of scientists to this field.