MOLECULAR BASIS OF CANCER/SIGNALING TO CELL GROWTH/DEATH

我们对细胞生长和死亡是如何调控的，以及控制这些细胞反应的信号通路的理解已经取得了相当大的进展。最近，在理解这些途径如何相交，以及放松对一种反应的管制如何影响其他反应方面，取得了令人兴奋的新进展。现在清楚的是，驱动细胞增殖的致癌改变也激活了生长抑制通路，而信号转导细胞生长、死亡和存活的通路可以密切地联系在一起，并在同一信号下被激活。肿瘤细胞的进展反映了允许恶性细胞存活和生长的补充性反应途径的扰动。这次会议将把细胞生长和凋亡的区域与调节它们的信号转导机制结合在一起，以帮助巩固我们对这些反应是如何在正常细胞中调节的理解，以及肿瘤进展所需的放松调控模式。发言者的选择主要是根据对会议总体科学目标的贡献。这三位共同组织者代表了在信号转导和癌症细胞生长和死亡调控领域的广泛专业知识，这些都是我们希望在会议中聚集在一起的主题。将这些领域聚集在一个会议上是一个新的步骤，将引起许多癌症生物学家的广泛兴趣，特别适合进入该领域的新一代年轻科学家。幸运的是，妇女专家很好地代表了这些领域，她们作为特邀发言者和组织者都得到了很好的代表。这次会议也将引起制药业的特别兴趣，来自公司的演讲者也包括在该计划中。

Considerable advances have been made in our understanding of how cell growth and death are regulated, and the signaling pathways that control these cellular responses. Recently, exciting new advances have been made in understanding how these pathways intersect, and how deregulation of one response impinges on others. It is now clear that oncogenic alterations that drive cell proliferation also activate growth inhibitory pathways, and pathways that signal cell growth, death and survival can be intimately linked and activated in response to the same signal. Tumor cell progression is a reflection of perturbations in complementary response pathways that allow malignant cells to survive and grow. This meeting will bring together areas of cell growth and apoptosis with signal transduction mechanisms that regulate them, to help consolidate our understanding of how these responses are regulated in normal cells and patterns of deregulation that are required for tumor progression. The choice of speakers has been based primarily on the contribution to the overall scientific goal of the conference. The three co-organizers represent a wide range of expertise in the areas of signal transduction and regulation of cell growth and death in cancers, the subjects we are hoping to bring together in the meeting. Bringing together these fields in one meeting is a new step that will be of wide interest to many cancer biologists, and will be particularly appropriate for the new generation of younger scientists entering the field. Fortunately these areas are well represented by experts who are women, who are well represented as both invited speakers and organizers. This meeting will also be of particular interest to the pharmaceutical industry and speakers from companies are also included in the program.