TREATMENT OF DEPRESSION IN PARENTS--IMPACT ON CHILDREN

描述(改编自申请人的摘要)：建议的项目将 父母抑郁治疗对儿童心理健康影响的研究 社会情绪调适。该项目将与两个新的 被诊断为重度抑郁症的成年人的NIMH治疗研究 无序。第一个是在范德比尔特进行的两个地点的研究 大学(Pi，Steve Hollon，博士)在宾夕法尼亚大学 (PI，Rob DeRubeis，博士)第二项研究将在芝加哥大学进行。 华盛顿(PI，尼尔·雅各布森博士)。在这三个网站上，640名成年人 将接受认知疗法、药物疗法或安慰剂(外加 华盛顿大学的行为细胞)。根据上一年收集的初步数据 四个月后，我们估计大约25%的患者会有孩子 年龄在8岁到16岁之间，并同意参加。这些初步的 数据为该项目的可行性和可接受性提供了证据， 研究表明，目前抑郁父母的目标儿童是 经历显著程度的症状和功能障碍。建议数 该项目将涉及对索引子项目的全面评估 关于父母进入医院时的精神病态和功能 治疗研究，分别于2、4、8、12、18、24个月复查。一组对照 父母一生中没有精神疾病和医疗疾病的孩子 精神障碍也将被包括在内。 这项研究的主要目的是：(A)审查 (B)父母抑郁程度降低，子女功能发生变化； 探索这些变化的可能中介，包括亲子关系 关系、婚姻功能、压力源和认知；及(C) 测试儿童适应的变化，假设的中介，以及 父母和孩子的症状之间的关系随着 父级接受的处理类型。数据分析将涉及 重复测量的传统方法&多元方差分析 以及一种更具一般性和创新性的个人成长曲线方法 使用协方差结构分析进行建模。这项研究代表了一项真正的 独一无二的机会加深我们对联系汇率的理论理解 父母和孩子之间的精神病理学，可以作为指导 为高危人群制定预防性干预措施。

DESCRIPTION (Adapted from applicant's abstract): The proposed project will study the impact of treating parental depression on children's socio-emotional adjustment. This project will interface with two newly funded NIMH treatment studies of adults diagnosed with major depressive disorder. The first is a two-site study being conducted at Vanderbilt University (PI, Steve Hollon, Ph.D.) and at the University of Pennsylvania (PI, Rob DeRubeis, Ph.D.). The second study will be at the University of Washington (PI, Neil Jacobson, Ph.D.). Across the three sites, 640 adults will receive cognitive therapy, pharmacotherapy, or placebo (plus a behavioral cell at UW). Based on preliminary data collected in the last four months, we estimate that about 25% of the patients will have children between 8 and 16 years old and will agree to participate. These preliminary data provide evidence of the feasibility and acceptability of the project, and showed that the targeted children of currently depressed parents were experiencing significant levels of symptoms and dysfunction. The proposed project will involve a comprehensive assessment of an index child with regard to psychopathology and functioning at the time the parent enters the treatment study and again at 2,4,8,12,18, and 24 months. A comparison group of children whose parents are lifetime-free of psychiatric and medical disorders also will be included. The primary aims of the study are: (a) to examine the relation between decreases in parent's depression and changes in children's functioning;(b) to explore possible mediators of these changes including the parent-child relationship, marital functioning, stressors, and cognitions; and (c) to test whether changes in child adaptation, the hypothesized mediators, and the relation between parent and child symptoms differ as a function of the type of treatment the parent received. Data analysis will involve traditional methods of repeated measures multivariate analyses of variance and a more general and innovative approach of individual growth curve modeling using covariance structure analysis. This study represents a truly unique opportunity to further our theoretical understanding of the link between parent and child psychopathology that can serve as a guide for the development of preventive interventions for high risk populations.