Topical Estrogen/CB Patch for Wound Healing in Elderly

提出了一种局部雌激素贴剂的开发，该贴剂包括可生物降解的基于壳聚糖的生物聚合物（CB），以加速老年患者的伤口愈合。急性皮肤伤口愈合延迟导致局部感染、伤口裂开以及向慢性不愈合伤口的转变。最近的临床数据表明，使用局部雌激素透皮贴剂的好处，以加速伤口愈合的老年患者。雌激素治疗的缺点之一是更大的疤痕形成。皮肤瘢痕形成是一个主要的临床问题，涉及功能障碍和生长受限。初步研究表明，CB存在时成纤维细胞增殖增加。此外，CB已被报道在体内减少瘢痕形成。在本I期可行性研究中，我们建议：（1）在动物研究中检查局部雌激素/CB贴剂用于伤口愈合的速率和瘢痕形成潜力，以及（2）通过初步人体研究确认动物数据。该申请的长期目标是开发一种雌激素贴片，加速老年人的修复速度和愈合质量。拟议的商业应用：局部雌激素贴片可能是一种可行的，加速伤口愈合的治疗老年人。此外，预期使用显示减少的瘢痕形成的基于壳聚糖的生物聚合物基质与雌激素一起为伤口愈合应用提供比当前商业经皮雌激素贴剂更好的替代方案。

The development of a topical estrogen patch including a biodegradable chitosan-based biopolymer (CB) to accelerate wound healing in the elderly patients is proposed. Delays in acute cutaneous wound healing lead to local infections, wound dehiscence, and a transition toward chronic, nonhealing wound. Recent clinical data have shown the benefit of using a topical estrogen transdermal patch to accelerate wound healing in elderly patients. One of the disadvantages of estrogen therapy is greater scar formation. Cutaneous scarring is a major clinical problem concerning functional impairment and restricted growth. Preliminary studies have shown increased fibroblast proliferation in the presence of CB. In addition, CB has been reported to reduce scar formation in vivo. In this Phase I feasibility study we propose: (1) to examine the rate and scarring potential of the topical estrogen/CB patch for wound healing in animal studies and (2) to confirm the animal data with preliminary human studies. The long-term goal of the proposed application is to develop an estrogen patch which accelerates the rate of repair as well as the quality of healing in the elderly. PROPOSED COMMERCIAL APPLICATIONS: A topical estrogen patch could be a viable, accelerated wound healing treatment in the elderly. In addition, the use of a chitosan-based biopolymer matrix showing reduced scar formation, together with the estrogen, is expected to provide a better alternative than current commercial transdermal estrogen patches for wound healing applications.