ULTRA HIGH RESOLUTION SQUID MAGNETOMETERS FOR BIOLOGICAL

说明(改编自申请人摘要)：建议的目标 研究方向是开发超高分辨率、薄膜低温 超导(LTS)SQUID磁强计(UHRSM) 皮卡循环。UHRSM将针对磁场成像进行优化 由动作电流、损伤电流和发育电流产生，残留 离体活组织和小鼠的磁化强度和磁化率 实验动物制剂。在第一阶段，申请者在 鱿鱼的设计和制造已经生产出了可靠、操作简单、 带有集成拾取线圈的廉价鱿鱼传感器，其磁通噪声为 可与市面上最好的鱿鱼传感器相媲美。整合了 将鱿鱼传感器送入低温系统，产生了一个原型仪器 目前被纳入范德比尔特的一项积极的研究计划 大学。他们目前的设计允许窗口到鱿鱼的间距小于 20 mm。建议在第二阶段项目下开发的原型将是 一种廉价、模块化、可定制的台式LTS Squid仪器，用于 空间分辨率低于100 mm和场敏感度的生物学研究 约为1pt/(平方根赫兹)。拟议的文书将能够 进行任何其他电学或磁学都不可能的测量 仪器，并应导致对细胞生物学和电学的新见解 和磁生理学。将进一步利用现有的专业知识来 开发和改进用于普通和定制生物磁学的SQUID传感器 需要更高灵敏度的SQUID磁强计和 梯度计，但空间分辨率较低。 建议的商业应用： 低温技术，鱿鱼设计方面的专业知识，以及他们的STTR赠款，将使我们能够 瞄准具有灵敏度的空间分辨率低于100微米的鱿鱼显微镜 约1 pT/hz-1/2。LTS SQUID支持具有更高带宽的新测量， 由于优越的信噪比，更高的空间分辨率和更快的扫描速度。这种工具的市场不是很大，但我们确信能卖出5-10美元 每年主要用于研究的系统。然而，如果该仪器被广泛接受，例如，作为免疫诊断行业的质量控制仪器或 作为对电子元件进行无损检测的工具，我们每年可以销售数十套系统。

DESCRIPTION (Adapted from Applicant's Abstract): The objective of the proposed research is to develop ultra-high resolution, thin film low-temperature superconductivity (LTS) SQUID magnetometers (UHRSM) with integrated pickup-loops. The UHRSM will be optimized for imaging of the magnetic fields produced by action currents, injury and developmental currents, remanent magnetization, and magnetic susceptibility in isolated living tissue and small experimental animal preparations. During Phase I, the applicants innovation in SQUID design and fabrication already produced a reliable, simple to operate, inexpensive SQUID sensor with integrated pick-up coils, whose flux noise was comparable to the best commercially available SQUID sensors. The integration of the SQUID sensor into a cryogenic system resulted in a prototype instrument currently incorporated into an active research program at Vanderbilt University. Their present design allows a window-to-SQUID spacing of less than 20mm. The prototype proposed to be developed under the Phase II project will be an inexpensive, modular, customizable, bench-top LTS SQUID instrument for biological research with spatial resolution below 100mm and field sensitivities on the order of 1pT/(square root Hz). The proposed instrument will be capable of making measurements that are impossible with any other electric or magnetic instrument, and should lead to new insights into cellular biology and electro- and magnetophysiology. The existing expertise will be exploited further to develop and improve SQUID sensors for general and custom biomagnetic applications which require higher-sensitivity SQUID magnetometers and gradiometers but lower spatial resolution. PROPOSED COMMERCIAL APPLICATION: The cryogenic technology, the expertise in SQUID design, and they STTR grant would allow us to target SQUID microscopes with spatial resolutions below 100 microm with sensitivities around 1 pT/Hz-1/2. The LTS SQUIDs enables new measurements with a higher bandwidth, a higher spatial resolution and a much faster scanning rate due to a superior signal to noise ratio. The market for such an instrument is not enormous, but we are convinced to sell 5-10 systems mainly used in research per year. However, should the instrument be widely accepted, for example, as quality control instrument in the immunodiagnostic industry or as instrument to perform NDE on electronic components, we could sell tens of systems per year.