Inorganic Ion Exchanger for use in 82Sr/82Rb Separations

描述（由申请人提供）：82Rb，正电子发射放射性核素 在心脏正电子发射断层扫描（PET）中得到广泛应用 成像，以发生器的形式提供给医生。82Sr是 固定在离子交换柱上，需要时洗脱82Rb。水合 二氧化锡是目前离子交换材料的选择，但离子交换技术的进展， 交换材料意味着新的，更合适的材料现在 available.母体82Sr是一种昂贵的同位素，并且是由 靶材料（如钼）的质子辐照，然后进行广泛的 处理以分离纯的82Sr。 SBIR第二阶段项目将使用九钛酸钠，一种先进的 锶选择性离子交换材料，以简化82Sr从 目标，并作为82 Sr在82 Rb发生器的冰糕。更高效 将开发目标处理技术，从而减少目标 处理时间，减少废物产生，提高82Sr产量，因此 降低了82Sr产品的成本。82Rb发生器寿命将延长， 并且获得82Sr和85Sr的穿透减少。的这两个方面 该项目将降低82Rb PET的成本，并减少患者暴露于 85Sr和82Sr。 拟定商业应用： 改进后的发生器将与现有的自动82Rb输注系统兼容，从而在目前使用82Rb的医疗中心得到广泛应用。改进的靶处理流程也将有助于从靶中分离其他同位素，例如具有医学应用的68Ge。

DESCRIPTION (Provided by Applicant): 82Rb, a positron-emitting radionuclide that finds extensive use in Positron Emission Tomography (PET) for heart imaging, is supplied to physicians in the form of a generator. 82Sr is immobilized on an ion exchange column and 82Rb eluted when required. Hydrous tin dioxide is the current ion exchange material of choice, but advances in ion exchange materials have meant that new, more suitable materials are now available. The parent 82Sr is an expensive isotope, and is produced by the proton irradiation of target materials (e.g. molybdenum) followed by extensive processing to isolate pure 82Sr. This SBIR Phase II project will use sodium nonatitanate, an advanced strontium-selective ion exchange material, to simplify 82Sr isolation from targets, and as a sorbet for 82Sr in 82Rb generators. New, more efficient target processing techniques will be developed, leading to decreased target processing times, decreased waste generation, improved 82Sr yield, and thus a decrease in the cost of the 82Sr product. 82Rb generator life will be extended, and a decrease in breakthrough of 82Sr and 85Sr obtained. These two aspects of the project will lower the cost of 82Rb PET and decrease patient exposure to 85Sr and 82Sr. PROPOSED COMMERCIAL APPLICATION: The improved generator will be compatible with existing automated 82Rb infusion systems, leading to widespread application at medical centers currently administering 82Rb. Improved target processing flowsheets will also aid in the seperation of other isotopes from targets, e.g. 68Ge, which have medical applications.