ALZHEIMERS DISEASE RESEARCH CENTER

这个阿尔茨海默病研究中心（ADRC）的目标，（主任： Lindy Harrell，医学博士，哲学博士、和副董事丹尼尔马森，J.D.， 哲学博士、Michael Wessels，医学博士）是建立一个临床和基础 科学研究对阿尔茨海默病（AD）病理学的影响。 该自抗扰控制器由5个核心和4个“R 01”型项目组成。的 管理矿石将提供所有可见性的实施 通过试点赠款（即，新的调查员），并每月 研讨会系列和与其他ADRC/ADCC的互动。临床核心 将招募并每年随访轻度和中度AD患者， 正常对照组，由2名神经科医生诊断（受试者25%为非洲人， 美国人，75%的白色，种族混合的杰斐逊县），将 提供1）生物统计服务，2）组织收集，以及3） 患者为研究者。神经心理电池，提供 研究者要求的其他神经心理学测试，以及 开发分析纵向数据的方法。神经病理学核心 将获得诊断，处理和存储组织（大脑，CSF）， 这些都是调查人员可以使用的。信息传输核心将提供 对医生、非专业人员和准专业人员社区的教育（ 强调非洲裔美国人），保持一个发言人局， 护理人员通讯，AD信息包，添加1-800电话 行，继续我们的年度CME会议，添加主页上的世界 网络，并通过多媒体手段传播ADRC的研究。第一 三个“R 01”项目主题相关，以了解AD如何 患者失去了特殊能力。项目1将审查 了解AD患者在驾驶刺激器下的认知变化 与有缺陷的驾驶和随时间的变化有关。计划2 将检查影响护理人员的行为问题，以确定 电话干预减轻了他们的负担。项目3将审查 经济能力的纵向丧失及其神经心理学 基础项目4的不同之处在于， （可调节Na+、K+通道和神经营养因子） 在AD和衰老中。政府大力支持这个发展检讨委员会， 在职业和经济上，支付全额工资（大约 46，000美元），以及更新人才资源计划 空间（200 000 - 250 000美元）。在UAB的ADRC将允许我们继续这两个 我们在AD方面的临床和基础科学研究工作， 扩展到新的研究领域。

The goal of this Alzheimer's Disease Research Center (ADRC), (Director: Lindy Harrell, M.D., Ph.D., and Associate Directors Daniel Marson, J.D., Ph.D., Michael Wyss, M.D.) is to foster a model of clinical and basic science research effect into the pathology of Alzheimer's Disease (AD). This ADRC is comprised of 5 cores and 4 "R01" type projects. The Administrative ore will provide the implementation of all visibility through pilot grants (i.e., bring new investigators), and a monthly seminar series and interactions with other ADRC/ADCC. The Clinical Core will recruit and annually follow mild and moderate AD patients and normal controls, diagnosed by 2 neurologists (subjects 25% African- American, 75% white, the racial mixture of Jefferson County), will provide 1) biostatistical services, 2) tissue collection, and 3) patients for investigators. Neuropsychological battery, provide additional neuropsychological tests requested by investigators, and develop methods to analyze longitudinal data. Neuropathological Core will obtain diagnoses, process and store tissue (brain, CSF), making these available to investigators. Information Transfer Core will provide education to physicians, lay and paraprofessional communities (with emphasis on African-Americans), maintained a Speakers Bureau, caregiver's newsletter, packets of AD information, add a 1-800 telephone line, continue our annual CME conferences, add a home page on the World Web, and disseminate ADRC research through multimedia means. The first three "R01" projects are thematically linked to understanding how AD patients lose specific capacities. Project 1 will examine performance of AD patients in a driving stimulator to understand the cognitive changes associated with defective driving and the changes over time. Project 2 will examine behavioral problems impacting caregivers to determine if telephone interventions modify their burden. Project 3 will examine the longitudinal loss of financial capabilities and their neuropsychological underpinnings. Project 4 differs in that the effects of neuregulins (which may regulate Na+, k+ channels and neurotrophins) will be accessed in AD and aging. The Administration strongly supports this ADRC both philosophically and financially, paying full salary (approximately $46,000) of the Administrator, and renovating Brain Resource Program space ($200,000-250,000). An ADRC at UAB would allow us to continue both our clinical and basic science research efforts in AD and would allow us to expand into new research areas.