DOES NEBULIZED DEXAMETHASONE IMPROVE PULMONARY FUNCTION IN NEONATES?

早产的一种常见的医学并发症是一种称为支气管肺发育不良的肺部疾病。这种疾病的传统治疗方法是静脉注射类固醇化合物地塞米松。静脉注射地塞米松通常会改善肺功能，并迅速减少对呼吸机支持的需求，但静脉注射这种化合物会产生许多全身副作用。这项研究是一项随机、双盲研究，旨在确定吸入地塞米松是否与静脉注射地塞米松一样有效(或更有效)，并确定吸入地塞米松是否与较少的全身副作用有关。这项研究在犹他大学医学中心和初级儿童医学中心的新生儿重症监护室进行。

A common medical complication of premature birth is a lung condition called bronchopulmonary dysplasia. The traditional treatment for this disorder is intravenous injections of a steroid compound, dexamethasone. Intravenous dexamethasone often results in improved pulmonary function and a rapid reduction in the need for ventilator support, but there are many systemic side effects from the intravenous administration of this compound. This study is a randomized, double-blinded study designed to determine if inhaled dexamethasone is as effective (or more effective) than intravenous injections of dexamethasone, and to determine if inhaled dexamethasone is associated with fewer systemic side effects. This study is done in the Newborn Intensive Care Unit at the University of Utah Medical Center and the Primary Children's Medical Center.