ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
批准号:
6415321
负责人:
Edmund K Waller
金额:
$29.31万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-12-01 至 2001-11-30
关键词:
B cell receptor T cell receptor autologous transplantation bone marrow bone marrow transplantation clinical research drug administration rate /duration hematopoietic stem cells homologous transplantation human subject human therapy evaluation immunotherapy passive immunization tissue donors transplantation immunology vaccines
中文摘要
迄今为止,还没有研究解决了何时应该进行供体免疫以在骨髓或干细胞收获物中具有最佳数量的致敏B和T细胞的问题。本研究旨在:确定对自体和同种异体BM供体进行疫苗接种的最佳时间间隔,以使骨髓移植物中抗原特异性B细胞和T细胞的频率最大化,证明过继免疫转移至接受来自最近接种的同种异体或自体供体的骨髓的BMT受体,并研究疫苗受体中的抗原特异性B细胞和T细胞应答。
英文摘要
No study to date has addressed the questions of when donor immunization should occur in order to have an optimal number of primed B and T cells in the bone marrow or the stem cell harvest. This study is designed to: determine the optimal time interval to vaccinate autologous and allogeneic BM donors in order to maximize the frequency of antigen specific B-cells and T-cells in the bone marrow graft, demonstrate transfer of adoptive immunity to BMT recipients who receive bone marrow from recently vaccinated allogeneic or autologous donors, and study antigen specific B-cell and T-cell responses in vaccine recipients.
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会议论文
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批准号:10402871
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资助金额:$74.68万
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Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantation
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Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantation
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批准号:10645013
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资助金额:$74.05万
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Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantation
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批准号:9893083
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资助金额:$37.87万
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财政年份:2019
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Manufacturing pathogen inactivated platelet lysate to treat corneal inflammation
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批准号:9048135
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资助金额:$14.93万
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财政年份:2015
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负责人:Edmund K Waller
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Using donor pDC to optimize GvHD and GvL in allogeneic stem cell transplantation
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批准号:9234506
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资助金额:$32.37万
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财政年份:2014
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负责人:Edmund K Waller
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依托单位:
Using donor pDC to optimize GvHD and GvL in allogeneic stem cell transplantation
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批准号:8837590
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项目类别:
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资助金额:$32.37万
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财政年份:2014
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负责人:Edmund K Waller
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依托单位:
Using donor pDC to optimize GvHD and GvL in allogeneic stem cell transplantation
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批准号:8630742
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项目类别:
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资助金额:$32.37万
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财政年份:2014
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负责人:Edmund K Waller
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依托单位:
CLINICAL TRIALS- SHARED RESOURCES
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批准号:7944908
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项目类别:
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资助金额:$7.07万
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财政年份:2009
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负责人:Edmund K Waller
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依托单位:
Modified Donor Lymphocytes Infusion (mDLI) for Rapid Immune Reconstitution
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批准号:8342005
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项目类别:
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资助金额:$33.7万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
Project 3: Red cell transfusions and donor T-cell activation in allo-stem cell t
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批准号:9100838
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项目类别:
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资助金额:$34.2万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
Project 3: Red cell transfusions and donor T-cell activation in allo-stem cell t
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批准号:9271224
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项目类别:
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资助金额:$33.31万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
Project 3: Red cell transfusions and donor T-cell activation in allo-stem cell t
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批准号:8794967
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项目类别:
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资助金额:$37.71万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
Immunologic and Virologic Monitoring Laboratory Core
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批准号:8342008
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项目类别:
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资助金额:$22.55万
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财政年份:2008
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负责人:Edmund K Waller
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依托单位:
ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
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批准号:6586010
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项目类别:
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资助金额:$29.31万
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财政年份:2001
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负责人:Edmund K Waller
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依托单位:
ADOPTIVE TRANSFER OF IMMUNITY IN BONE MARROW TRANSPLANTATION
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批准号:6565715
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项目类别:
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资助金额:$29.31万
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财政年份:2001
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负责人:Edmund K Waller
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依托单位:
Separating Antitumor & GvHD in Allogeneic T-Cells
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批准号:7253282
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项目类别:
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资助金额:$29.88万
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财政年份:1998
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负责人:Edmund K Waller
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依托单位:
ANTILEUKEMIC EFFECT OF IRRADIATED ALLOGENEIC LYMPHOCYTES
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批准号:2694992
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项目类别:
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资助金额:$22.74万
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财政年份:1998
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负责人:Edmund K Waller
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依托单位:
ANTILEUKEMIC EFFECT OF IRRADIATED ALLOGENEIC LYMPHOCYTES
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批准号:6173252
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项目类别:
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资助金额:$23.87万
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财政年份:1998
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负责人:Edmund K Waller
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依托单位:
Separating Antitumor & GvHD in Allogeneic T-Cells
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批准号:6941596
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项目类别:
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资助金额:$30.14万
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财政年份:1998
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负责人:Edmund K Waller
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依托单位:
海外基金