GENETIC MAPPING OF TYPE 2 DIABETIC NEPHROPATHY: END STAGE RENAL DISEASE

终末期肾病（ESRD）是一种迟发性多因素 主要发生在糖尿病患者亚群中的疾病 糖尿病、高血压或慢性肾小球肾炎。 ESRD发病率 每年的死亡率约为20%。 ESRD家族聚集性和家族聚集性是一个更强大的 预测是否患有糖尿病的个体， 高血压或慢性肾小球肾炎会发展为终末期肾病。 然而，没有特定的遗传机制负责肾 最终导致终末期肾病的功能损害尚未确定。 我们正在招募150对ESRD和类型一致的受影响同胞对 2例糖尿病，100对兄弟姐妹与ESRD不一致（但与ESRD一致）。 2型糖尿病）和200名来自 血液透析、腹膜透析和移植中心， 研究确定ESRD的遗传风险因素。 我们正在收集 广泛的家族史和病史，与ESRD相关， 所有家庭成员都被招募到研究中。 罪要归 从同意的家庭成员获得。 将使用以下方法分析数据： 无模型链接分析 预计此数据集将非常复杂 我们将不得不按种族/民族细分数据进行分析。 我们预计，这项研究将导致识别基因（S） 对于ESRD。

End-stage renal disease (ESRD) is a late-onset multifactorial disease that primarily occurs in a subset of patients with diabetes mellitus, hypertension or chronic glomerulonephritis. ESRD incidence is rising with an annual mortality of about 20% in incident cases. ESRD clusters in families and familial aggregation is a more powerful predictor of whether an individual with diabetes mellitus, hypertension or chronic glomerulonephritis will develop ESRD. However, no particular genetic mechanism responsible for the renal function damage that ultimately leads to ESRD has yet been identified. We are recruiting 150 affected sib pairs concordant for ESRD and Type 2 diabetes, and 100 sib pairs discordant for ESRD (but concordant for Type 2 diabetes mellitus) and 200 additional family members from hemodialysis, peritoneal dialysis and transplant centers as part of a study to identify genetic risk factors for ESRD. We are collecting extensive family history and medical history, as related to ESRD, on all members of the family recruited into the study. Blood will be obtained from consenting family members. Data will be analyzed using model-free linkage analysis. This dataset is expected to be complex and we will have to subdivide the data by race/ethnicity for analysis. We anticipate that this study will lead to identification of gene(s) for ESRD.