Antiestrotrophic Mechanisms of Alphafetoprotein Peptides

描述：（由申请人提供）甲胎蛋白（AFP）和合成 肽衍生物是有效的抗雌激素剂， 作为一类新的乳腺癌治疗药物的潜力。的 全长蛋白质的活性定位在八个氨基酸内 从天然人甲胎蛋白衍生的肽， 肽的主要目标的发展。甲胎蛋白肽阻断 雌激素刺激正常和肿瘤组织的生长。抗氧化剂 AFP及其衍生肽的活性是雌激素所特有的 在体内和体外含有受体的细胞。直到最近， 对AFP片段的抗雌激素活性进行了研究 和肽，重点是识别蛋白质活性位点，但 关于AFP肽作用的细胞机制知之甚少。的 该项目的目标是发现的基本分子机制（S） AFP肽活性。为了实现这一目标，有必要确定 参与AFP作用的细胞机制的组成部分，以便我们可以 了解AFP肽活性的生物化学和分子基础。的 这项工作的结果，预计将有助于发展新的 治疗目标，并将提供有关的有价值的信息， AFP肽作为预防、治疗和诊断试剂的潜力 乳腺癌

DESCRIPTION: (provided by the applicant) Alphafetoprotein (AFP) and synthetic peptide derivatives are potent antiestrotrophic agents with significant potential as a novel class of therapeutic agents against breast cancer. The activity of the full-length protein is localized within an eight amino acid peptide derived from the native human alphafetoprotein elevating this synthetic peptide to a primary target for development. AFP peptide blocks the estrogen-stimulated growth of normal and neoplastic tissues. The anti-oncotic activity of AFP and its derivative peptides is unique to estrogen receptor-containing cells in vivo and in vitro. Until recently, much effort has been invested into the study of the antiestrotrophic activity of AFP fragments and peptides, with the focus on identification of the protein active site, yet very little is known about the cellular mechanism of AFP peptide action. The goal of this project is to discover the fundamental molecular mechanism(s) of AFP peptide activity. To accomplish this goal, it is necessary to identify the components of the cellular machinery involved in AFP action so that we may understand the biochemical and molecular basis of AFP peptide activity. The result of this work is expected to contribute to the development of novel therapeutic targets and will provide valuable information concerning the potential of AFP peptides as agents in the prevention, treatment, and diagnosis of breast cancer.