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WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE

WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
使用乙基氨磷汀的全肝辐射剂量递增试验
批准号：
6303452
负责人：
CORNELIUS J MCGINN
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6303452
关键词：
clinical research clinical trial phase I combination cancer therapy human subject liver neoplasms neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy radiation therapy dosage thiophosphate whole body irradiation dosage

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中文摘要
翻译
虽然放射疗法已被证明在治疗始于肝脏或扩散到肝脏的癌症患者方面是有效的，但它在治疗整个肝脏方面的有效性受到可安全耐受的低总剂量的限制。在这项1期研究中，乙醇（氨磷汀）将被用于尝试使整个肝脏获得更高的总剂量。这种药物已被开发用于选择性地保护正常组织免受化疗和放疗的毒性。
英文摘要
Although radiation has proven efficacy in the treatment of patients with cancers that started in or spread to the liver, its usefulness in the treatment of the whole liver is limited by the low total dose that can be safely tolerated. In this phase 1 study, Ethyol (amifostine) will be used in attempt to allow delivery of a higher total dose to the whole liver. This agent has been developed to selectively protect normal tissues against the toxicities of chemotherapy and radiation.
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WHOLE LIVER RADIATION DOSE ESCALATION TRIAL UTILIZING ETHYOL AMIFOSTINE
WHOLE LIVER RADIATION DOSE ESCALATION FOR INTRAHEPATIC CANCERS
LOW DOSE LIVER IRRADIATION WITH HEPATIC ARTERIAL CHEMOTHERAPY FOR CANCER
RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
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