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EFFECT OF CORTICOTROPHIN RELEASING HORMONE ON RELEASE OF ACTH & CORTISOL

EFFECT OF CORTICOTROPHIN RELEASING HORMONE ON RELEASE OF ACTH & CORTISOL
促肾上腺皮质激素释放激素对 ACTH 释放的影响
批准号:
6307752
负责人:
SUSAN SCOTT
金额:
$2.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-12-01 至 2000-11-30

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中文摘要
翻译
在成人中,在严重疾病的情况下,促肾上腺皮质激素释放随着CRH的挑战而增强。在我们的结果中,ACTH测试表明,在出生第一周生病的早产儿中,皮质醇释放峰值降低,4天大的婴儿比6天大的婴儿更大。这些结果表明,与成人在疾病状态下激活HPA不同,患病的早产儿可能不会以这种方式做出反应,并且可能处于低释放皮质醇的风险中。
英文摘要
In the adult, there is potentiation of ACTH release with CRH challenge in the setting of severe illness. In our results, the ACTH test demonstrates that peak cortisol release is decreased in premature infants that have been ill during the first week of life, is greater in the 4 day old than the six day old infant. These results suggest that, unlike the adult where the HPA is activated during a state of illness, the ill premature infaants may not respond in this fashion and may be at-risk of low release cortisol.
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