MOLECULAR BASIS FOR DYSLEXIA IN KLINEFELTERS SYNDROME

本研究的目的是研究Klinefelter综合征患者在多大程度上患有阅读障碍和行为及学习障碍，以及睾酮替代疗法是否会改变这些障碍。患有Klinefelter综合征的性腺功能减退患者在睾酮治疗前后接受详细的神经心理学测试。 参加这项研究的男性也需要抽血建立淋巴母细胞系，目的是检查X染色体的遗传差异，看看它们是否影响神经心理障碍的发生和严重程度。 这项研究利用了Harbor-UCLA的亲本GCRC（招募和测试患者）与Cedars-Sinai GCRC（建立淋巴母细胞系）之间的协同作用。

The purpose of this research is to study to what degree patients with Klinefelter syndrome suffer from dyslexia and behavioral and learning disabilities and if testosterone replacement therapy alters these disabilities. Hypogonadal patients with Klinefelter syndrome undergo detailed neuropsychological testing before and after testosterone treatment. Men enrolled in the study also have blood drawn for the establishment of lymphoblastoid cell lines, with the goal being to examine genetic differences in the X chromosome to see if they impact on the occurrence and severity of the neuropsychological disabilities. This study capitalizes on synergy between the parent GCRC at Harbor-UCLA, where the patients are recruited and tested, and the Cedars-Sinai GCRC, where the lymphoblastoid cell lines are established.