GENERAL CLINICAL RESEARCH CENTER

这是一个有竞争力的更新申请洛厄尔P。一般临床研究中心（GCRC），于1993年12月在康涅狄格大学健康中心（UCHC）成立。在最初的四年里，GCRC作为中央门诊设施大幅增长。虽然我们90%以上的研究是在门诊患者中进行的，但住院患者的研究是在指定的内外科病房或专科病房（如布恩骨髓移植病房或UCHC的成人和新生儿重症监护病房）的病床上进行的。此次更新申请包含37项研究方案，而首次申请时为23项。这一应用的重点仍然是基础科学家和临床研究人员之间相互作用的研究，特别是将分子生物学和人类遗传学的新方法应用于疾病发病机理的研究。本次更新申请中的方案涵盖范围广泛，包括以下研究：1）酒精和药物滥用，2）骨质疏松症和代谢性骨病，3）与HIV相关的神经系统变化，4）蜱传感染的神经系统并发症，5）精神分裂症的遗传学，6）心力衰竭的发病机制，7）癌症和硬皮病的免疫治疗，8）前列腺炎的发病机制，9）骨干燥综合征（Sjogren's syndrome）。GCRC已成为一个主要的培训中心。GCRC工作人员开发了一个介绍临床研究方法的课程，并提供了新的学生选修课。UCHC继续通过为基础设施提供资金来支持GCRC。此外，还提供了额外的空间，以便扩大我们的设施。GCRC在临床研究活动和生产力方面表现出持续增长。拟议中的研究应该提高我们对发病机制的理解，并提高我们治疗影响大量美国人的疾病的能力。

This is a competitive renewal application for the Lowell P. Weicker Jr. General Clinical Research Center (GCRC), which was established at the University of Connecticut Health Center (UCHC) in December, 1993. During its initial four years, the GCRC has grown substantially as a central outpatient facility. While over 90% of our studies are with outpatients, inpatient studies have been carried out using beds on a designated medical-surgical unit or a specialized unit, such as the Boone Marrow Transplant Unit or the Adult and Neonatal Intensive Care Units of UCHC.. This renewal application contains 37 research protocols, compared to 23 in the initial application. The emphasis in this application continued to be on studies involving interactions between basic scientists and clinical investigators, particular in the application of new methods of molecular biology and human genetics to the study of the pathogenesis of disease. The protocols in this renewal application cover a wide range, including studies on 1) alcohol and substance abuse, 2) osteoporosis and metabolic bone disease, 3) neurologic changes associated with HIV, 4) neurologic complications of tick-borne infections, 5) genetics of schizophrenia, 6) pathogenesis of heart failure, 7) immunotherapy for cancer and scleroderma, 8) pathogenesis of prostatitis, 9) oral mucositis in bone Sjogren's syndrome. The GCRC has become a major center for training. GCRC staff have developed an introductory course on methods of clinical research and offered new student electives. UCHC continues to make a substantial commitment to support the GCRC by providing funding for infrastructure. Moreover, additional space has been provided to allow for expansion of our facilities. The GCRC has shown continuous growth in clinical research activity and productivity. The proposed research should enhance our understanding of pathogenesis and increase our ability to treat conditions which affect large numbers of Americans.