LEAD AND OTHER NEUROTOXINS AS RISK FACTORS FOR AMYOTROPH

我们进行了一项ALS病例对照研究，以调查终生暴露于铅和其他神经毒素（包括汞、溶剂和杀虫剂）的作用。现场工作已完成；纳入110例临床ALS病例、31例临床对照和270例人群对照。我们通过三种方式评估铅暴露：我们使用x射线荧光测量骨铅；我们测量了血铅；我们进行了一次结构化的面对面访谈来收集潜在的职业，居住和生活方式暴露源的信息。ALS与血铅和骨铅以及职业性铅暴露有关，但与居住或生活方式暴露无关。我们还发现，ALS与吸烟有关，但与饮酒无关。ALS与饮食中的番茄红素有关，而与其他抗氧化微量营养素或饮食中的其他成分无关。

We have conducted a case-control study of ALS to investigate the role of cumulative lifetime exposure to lead and other neurotoxins, including mercury, solvents, and pesticides. Field work is complete; 110 clinic-based ALS cases, 31 clinic controls, and 270 populations controls were enrolled. We assessed lead exposure in three ways: we measured bone lead using x-ray fluorescence; we measured blood lead; and we administered a structure in-person interview to gather information on potential occupation, residential and lifestyle sources of exposure. ALS was associated with both blood and bone lead and with occupational exposure to lead, but not with residential or lifestyle exposures. We also found that ALS was associated with cigarette smoking but not with alcohol use. ALS was related to dietary lycopene but not to other antioxidant micronutrients or other components of diet.