3D Nanomaterial Architectures for Tissue Scaffold Applications.

该项目将开发用于癌细胞体外培养的泡沫和纤维复合材料中的纳米材料的3D支架，具有高度受控的表面化学，形态和机械性能。其目的是使用这些支架来解决癌细胞与微环境相互作用的不同方面以及治疗和治疗逃避的机制。此外，我们还将使用我们的纳米材料诱导和检测癌症干细胞分化。越来越清楚的是，癌症微环境的作用，特别是结构和形态，对于不同的癌症标志（包括侵袭和转移）至关重要。纳米材料（特别是新的层状材料族）提供了一个独特的机会来简化参数空间，具有结构类似物，允许物理形貌与化学完全分离，以及通过功能化控制所呈现的表面化学的能力

This project will develop 3D scaffolds of nanomaterials in foams and fibrous composites for in vitro culture of cancer cells, with highly controlled surface chemistry, morphology and mechanical properties. The aim is to use these scaffolds to address the different aspects of cancer cells' interactions with the microenvironment as well as mechanisms of treatment and treatment evasion. In addition, we will use our nanomaterials to induce and examine cancer stem cell differentiation.It is becoming increasingly clear that the role of the cancer microenvironment, the structure and morphology in particular, is of extreme importance for different cancer hallmarks including invasion and metastasis.Nanomaterials (especially the family of new layered materials) provide a unique opportunity to simplify the parameter space, with structural analogues allowing for the complete separation of physical topography from chemistry, and the ability to control the presented surface chemistry with functionalisation