A National Electron Diffraction Facility for Nanomaterial Structural Studies

用于纳米材料结构研究的国家电子衍射装置

基本信息

  • 批准号:
    EP/X014444/1
  • 负责人:
  • 金额:
    $ 195.21万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

Electron diffraction (ED) is about to become a quantitative technique that will be used routinely to solve and refine crystal structures from extremely small specimens. These materials are, at best, difficult to tackle with X-ray diffraction (XRD) and many are completely beyond the reach of current capabilities. The very different physics of electron scattering means that structures of crystals with grain sizes smaller than a micrometre, and materials containing light elements like hydrogen and lithium, can be solved.This step-change will be made possible by taking the methods and detectors currently used for XRD, which have been developed over decades to a high level, and combining them with a purpose-built electron diffractometer. The resulting equipment allows routine analysis of nanoscale materials. This new technology opens many doors, in some fields saving months of work in crystallisation and crystal growth. Unsurprisingly, there is intense interest both on a national and international level.Electron diffraction itself is not new, but the factors that allow it to reach beyond XRD, particularly multiple scattering, need to be considered when modelling the data produced in these measurements. This is still very much a work in progress, and it will be essential to bridge the gap between disciplines, bringing in knowledge and methods from electron microscopy, to develop the method to its full potential.These machines have become commercially available only in the last year. To remain competitive in structural science, the UK must invest in this area, and can take a global lead by doing so promptly. The widest benefit of this new capability for UK researchers will be provided by a national facility for ED that has both capacity and expertise to develop this nascent technology for routine and widespread use.The National Crystallography Service (NCS) at the University of Southampton (UoS) is well-placed to deliver such a facility, building on its success in routinely providing structure solution and refinement using high-value equipment that is unavailable to most researchers in their home institutions. The University of Warwick (UoW) has nationally leading electron microscopy and XRD facilities with a proven success in offering multiuser access. UoW also has a leading position in modelling and developing ED techniques and brings a suite of methods (cryogenic holders, heating holders, MEMS-based in-situ holders, graphene oxide support films) that will extend ED capabilities into new areas. Together, UoS and UoW will provide a dual site, single national facility that will build on existing world class lab infrastructure, deliver the technique immediately at both national and local scale, and develop the method going forward to take advantage of this opportunity for the UK.Four areas are identified as having the most to gain immediately from new ED techniques: pharmaceuticals; metal-organic frameworks; inorganic materials and molecular solids. Industry, in particular Pharma, realises the impact of ED and is keenly expressing a need for access to the technique.There is therefore strong support for the proposed facility from both academia and industry, and leading representatives from these communities in the UK have agreed to form an independent ED working group and act as champions to promote the method and facility. To understand how ED should develop, matching capacity and capabilities to the needs of the UK science community, the working group and the UoS/UoW team will undertake a landscaping exercise that will align with NCS national access cycles. This will allow new communities to be identified and aid strategically informed investment to grow UK capacity and research in the fundamental and essential area of atomic structure determination.The timing for this facility is ideal as ED technology now becoming available aligns with swathes of research communities demanding it.
电子衍射(ED)即将成为一种定量技术,它将被常规用于从极小的样品中解算和提炼晶体结构。这些材料充其量是很难用X射线衍射仪处理的,而且许多材料完全超出了目前的能力。电子散射的物理原理非常不同,这意味着可以解决粒度小于一微米的晶体以及含有氢和锂等轻元素的材料的结构。这种转变将通过将目前用于X射线衍射的方法和探测器提高到更高的水平,并将它们与专门建造的电子衍射仪相结合。由此产生的设备可以对纳米材料进行常规分析。这项新技术打开了许多大门,在一些领域节省了几个月的结晶和晶体生长工作。不出所料,在国家和国际层面上都引起了强烈的兴趣。电子衍射本身并不新鲜,但在对这些测量产生的数据进行建模时,需要考虑使其超越X射线衍射的因素,特别是多次散射。这在很大程度上仍然是一项正在进行的工作,必须弥合学科之间的差距,引进电子显微镜的知识和方法,以充分发挥该方法的潜力。这些机器直到去年才投入商业使用。为了保持在结构科学领域的竞争力,英国必须在这一领域进行投资,并迅速采取行动,从而引领全球。这一新能力为英国研究人员带来的最广泛好处将由ED的国家设施提供,该设施既有能力又有专业知识来开发这项新技术,用于常规和广泛使用。南安普顿大学(UoS)的国家晶体服务(NCS)处于有利地位,可以提供这种设施,因为它成功地利用高价值设备定期提供结构解决方案和精细化,这是大多数研究人员在本国机构无法获得的。华威大学(UOW)拥有全国领先的电子显微镜和X射线衍射仪设备,在提供多用户访问方面取得了成功。UOW还在建模和开发ED技术方面处于领先地位,并带来了一套方法(低温保持器、加热保持器、基于MEMS的原位保持器、氧化石墨烯支撑膜),这些方法将把ED能力扩展到新的领域。UOS和UOW将共同提供一个双站点、单一的国家设施,该设施将建立在现有的世界级实验室基础设施基础上,立即在国家和地方规模上交付技术,并在未来开发方法,以利用英国的这一机会。四个领域被确定为立即从新的ED技术中获益最多:制药;金属-有机框架;无机材料和分子固体。工业界,特别是医药行业,意识到ED的影响,并强烈表示需要使用该技术。因此,学术界和工业界都强烈支持拟议的设施,来自英国这些社区的主要代表已同意成立一个独立的ED工作组,并作为倡导者推广该方法和设施。为了了解教育部门应如何发展,使能力和能力与英国科学界的需求相匹配,工作组和密歇根大学/牛津大学团队将进行一项环境美化工作,使之与国家科学中心的国家接入周期保持一致。这将允许确定新的社区,并帮助进行战略性的投资,以提高英国在原子结构确定的基础和关键领域的能力和研究。这一设施的建立时机是理想的,因为现在可以获得ED技术,以满足大量研究社区的需求。

项目成果

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Simon Coles其他文献

Simon Coles的其他文献

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{{ truncateString('Simon Coles', 18)}}的其他基金

Core Equipment to leverage world class National Crystallography Service facilities
核心设备利用世界一流的国家晶体学服务设施
  • 批准号:
    EP/X034704/1
  • 财政年份:
    2023
  • 资助金额:
    $ 195.21万
  • 项目类别:
    Research Grant
The UK National Crystallography Service 2022-27
英国国家晶体学服务中心 2022-27
  • 批准号:
    EP/W02098X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 195.21万
  • 项目类别:
    Research Grant
An integrated 'workbench' environment for Quantum Crystallography
量子晶体学的集成“工作台”环境
  • 批准号:
    EP/W029588/1
  • 财政年份:
    2022
  • 资助金额:
    $ 195.21万
  • 项目类别:
    Research Grant
Core Equipment to underpin the National Crystallography Service 2020-
支撑国家晶体学服务2020的核心设备-
  • 批准号:
    EP/V032992/1
  • 财政年份:
    2020
  • 资助金额:
    $ 195.21万
  • 项目类别:
    Research Grant
An EPSRC National Research Facility to facilitate Data Science in the Physical Sciences: The Physical Sciences Data science Service (PSDS)
EPSRC 国家研究机构,旨在促进物理科学中的数据科学:物理科学数据科学服务 (PSDS)
  • 批准号:
    EP/S020357/1
  • 财政年份:
    2019
  • 资助金额:
    $ 195.21万
  • 项目类别:
    Research Grant

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