EFFECT OF LIPOXIN A4 AND PROSTAGLANDIN E2 IN ASSISSTED BONE HEALING

创伤后的骨愈合和修复涉及细胞和分子水平上的一系列复杂事件。本研究旨在确定局部应用最佳剂量的脂氧素A4(促进炎症消退)和前列腺素E2(低剂量刺激局部骨形成)将促进聚合物泡沫植入缺损后的愈合，从而开发一种加速骨沉积和促进愈合的治疗方法。

Bone healing and repair following trauma involves a complex series of events at both the cellular and molecular levels. This study aims to determine that local application of optimal dose of lipoxin A4 (promote resolution of inflammation) and prostaglandin E2 (low dosage stimulating localised bone formation) will promote healing following the placement of polymer foam in the defect, there by develop a therapy where bone deposition is accelerated and healing is enhanced.