Discovering the role of pH in regulating mitochondrial biogenesis, so as to improve the design of preventative programs aimed at healthy ageing

线粒体对生命至关重要，维持线粒体功能在预防许多与年龄有关的疾病的进展中起着重要作用。先前的研究表明，在体育活动期间，将肌肉pH值的下降降至最低，可以促进线粒体功能的更大改善。下一步是发现改变pH值对参与骨骼肌线粒体生物发生调节的信号蛋白和基因的急性和慢性活动诱导的变化的影响。这些实验将显著提高线粒体生物发生调控因素的知识基础，并有助于优化针对健康衰老的预防方案设计。

Mitochondria are essential for life, and maintaining mitochondrial function plays an important role in preventing the progression of many age-related diseases. It has previously been shown that minimising the decrease in muscle pH that occurs during physical activity promotes greater improvements in mitochondrial function. The next step is to discover the effects of altering pH on acute and chronic activity-induced changes in signalling proteins and genes that are involved in the regulation of skeletal muscle mitochondrial biogenesis. These experiments will significantly advance the knowledge base concerning factors regulating mitochondrial biogenesis, and will contribute to optimising the design of preventative programs aimed at healthy aging.