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EFFECT OF ANTIRESORPTIVES IN PATIENTS W/ PAGETS DISEASE

EFFECT OF ANTIRESORPTIVES IN PATIENTS W/ PAGETS DISEASE
抗吸收剂对佩吉特病患者的影响
批准号：
6450051
负责人：
JAN M BRUDER
金额：
$23.48万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-12-01 至 2001-11-30
来源：
https://reporter.nih.gov/project-details/6450051
关键词：
alendronate clinical research diphosphonate human subject human therapy evaluation interleukin 6 longitudinal human study measles virus osteitis deformans osteoclasts pathologic bone resorption physiologic bone resorption skeletal disorder chemotherapy

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中文摘要
翻译
佩吉特综合征是一种骨重建疾病。 这一过程是由破骨细胞介导的骨吸收增加开始的，随后是大量新的但异常的骨形成。 本研究将测定佩吉特病患者在开始用抗再吸收双膦酸盐阿仑膦酸盐进行预定治疗时和6个月治疗结束时外周血中破骨细胞前体的数量、IL-6的水平和麻疹病毒核衣壳mRNA的存在或不存在。 破骨细胞前体的数量和IL-6水平将与疾病的活性相关，如通过骨吸收和形成的血清和尿标记物的水平所确定的。
英文摘要
Paget's is a disorder of bone remodeling. The process is initiated by an increase in osteoclast mediated bone resorption followed by an abundance of new but abnormal bone formation. This study will determine the number of osteoclast precursors, the level of IL-6 and the presence or absence of measles virus nucleocapsid mRNA in the peripheral blood from patients with Paget's disease at the start of their scheduled treatment with the antiresorptive bisphosphonate alendronate and at the completion of the 6 month treatment. The number of osteoclast precursors and the IL-6 levels will be correlated with the activity of the disease as determined by the levels of serum and urine markers of bone resorption and formation.
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