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CATALYTIC SITE IN FURANOCOUMARIN-METABOLIC P450S

CATALYTIC SITE IN FURANOCOUMARIN-METABOLIC P450S
呋喃香豆素代谢 P450S 中的催化位点
批准号：
6385845
负责人：
Mary A Schuler
金额：
$27.0万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-12-01 至 2003-03-31
来源：
https://reporter.nih.gov/project-details/6385845
关键词：
Lepidoptera active sites alleles chemical models chemical structure function cytochrome P450 cytotoxicity detoxification enzyme activity enzyme substrate furocoumarin isozymes mass spectrometry molecular cloning nuclear magnetic resonance spectroscopy photoactivation polymerase chain reaction tissue /cell culture

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中文摘要
翻译
描述（改编自申请人的摘要）：呋喃香豆素是 天然存在的植物代谢物是极其有毒的，因为它们 与DNA中的嘧啶碱基和一般细胞蛋白质反应， 因为它们与P450可逆和不可逆地相互作用， 催化位点呋喃香豆素的这些光生物学特性已经被 用于治疗各种人类皮肤病， 它们的代谢机制及其对内源性药物的影响 代谢P450还没有很好地建立。我们可以了解到 通过研究P450的代谢和P450抑制机制， 在食草性昆虫中，专门以含有高浓度的 这些呋喃香豆素的线性和角形形式的水平。
英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): Furanocoumarins are naturally occurring plant metabolites that are extremely toxic because they react with pyrimidine bases in DNA and with general cellular proteins when photoactivated and because they interact reversibly and irreversibly with P450 catalytic sites. These photobiologic properties of furanocoumarins have been exploited for the treatment of a variety of human skin diseases even though the mechanisms for their metabolism and their effects on endogenous drug metabolizing P450s have not been well established. Much can be learned about their metabolism and mechanism of P450 inhibition by studying the P450s that are in herbivorous insects specialized to feed on host plants containing high levels of liner and angular forms of these furanocoumarins.
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Integrated Theoretical and Experimental Studies of P450 Structure and Function
Integrated Theoretical and Experimental Studies of P450 Structure and Function
Integrated Theoretical and Experimental Studies of P450 Structure and Function
Integrated Theoretical and Experimental Studies of P450 Structure and Function
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