HIV Pathogenesis, prevention and treatment in the Andes

描述(由申请人提供)：此IMPACTA Salud y Education acion/学校 公共卫生与Peruana Cayetano Heredia R03应用 申请资金以规划和准备CIPRA多项目的申请 P01适用于秘鲁和安第斯地区。本届CIPRA的主题将是 安第斯地区艾滋病毒/艾滋病的预防、发病和治疗。 秘鲁CIPRA的总体目标是：(L)进一步发展区域， 与艾滋病毒有关的研究的机构和调查能力 通过行政、实验室、 社区事务/行为研究、生物统计/数据管理和 开发/培训核心；以及2)支持以下具体研究项目 特别重要的是秘鲁和拉丁美洲的安第斯地区。这个 CIPRA包括5个核心：a)管理。B)实验室。C)生物统计学。d) 社区教育和发展；以及e)发展和培训。这个 CIPRA核心将提供培训、研究和行政支持，以及 在秘鲁进行的艾滋病毒研究的技术专长，并将直接 支持最多六个重大研究项目和小型发展研究 秘鲁CIPRA P01申请中的项目。所有内核都有监督内核 委员会，并设有监督的核心协调员职位。具体的 将在P0I申请中提出的主要研究项目建立在之前的基础上 美国国立卫生研究院资助的过去几年在秘鲁进行的研究项目 A)研究性传播疾病和艾滋病毒之间的生物和流行病学相互作用 为了开发和进行生物医学干预试验，以减少 性传播疾病和艾滋病毒传播；b)测试免疫学和临床结果， 一种简单的抗逆转录病毒方案的依从性和抗逆转录病毒耐药性 在艾滋病毒感染者中；c)评估行为疗法的疗效 对男男性接触者进行干预，以减少危险行为和性传播疾病/艾滋病毒的发病率； 确定普通人群和核心人群之间的性别混合模式 秘鲁的群体，特别是女性性工作者和双性恋男子；并评价 社区随机STD/HIV预防试验；e)评估 多药耐药的流行病学、传播预防和治疗 安第斯地区艾滋病毒感染者中的结核病；和，f)确定 快速诊断策略和有效干预措施减少围产儿出生 传播逆转录病毒，特别是艾滋病毒。目前还不清楚是什么 在艾滋病毒感染的治疗方面有经验，或者有什么规定 为秘鲁医生提供管理方面的培训 抗逆转录病毒疗法。

DESCRIPTION (provided by applicant): This Impacta Salud y Educacion/School of Public Health and Universidad Peruana Cayetano Heredia R03 application requests funding to plan and prepare an application for a CIPRA multi-project P01 application for Peru and the Andean region. The theme of this CIPRA will be prevention, pathogenesis and treatment of HIV/AIDS in the Andean region. The overall aims of the Peru CIPRA are: l) to further develop regional, institutional and investigative capacity for research related to HIV prevention, vaccine and treatment through administrative, laboratory, community affairs/behavioral research, biostatistics/data management and developmental/training cores; and 2) to support specific research projects of particular importance to Peru and the Andean region of Latin America. The CIPRA includes 5 cores: A) Administration. B) Laboratory. C) Biostatistics. D) Community Education and development; and E) Developmental and training. The CIPRA cores will provide training, research and administrative support, and technical expertise for HIV research conducted in Peru, and will directly support up to six major research projects and small developmental research projects in the Peru CIPRA P01 application. All cores have oversight Core Committees, and have core coordinator positions for supervision. The specific major research projects to be proposed in the P0I application build on prior NIH-funded research projects conducted in Peru over the past several years and are: a) To study biologic and epidemiologic interactions between STDs and HIV in order to develop and conduct trials of biomedical interventions to reduce STD and HIV transmission; b) To test immunologic and clinical outcomes, adherence, and antiretroviral resistance with a simple antiretroviral regimen in persons with HIV infection; c )To assess the efficacy of a behavioral intervention among MSM in reducing risk behaviors and STD/HIV incidence; d)To determine patterns of sexual mixing between the general population and core groups in Peru, particularly female sex workers and bisexual men; and evaluate a community-randomized STD/HIV prevention trial; e) To assess the epidemiology, prevention of transmission and treatment of multi-drug resistant tuberculosis in HIV-infected persons in the Andean Region; and, f)To identify rapid diagnostic strategies and effective interventions to reduce perinatal transmission of retroviruses, particularly HIV. It is not clear what experience is present in the treatment of HIV infection, or what provision is made to provide training for Peruvian physicians in the administration of antiretroviral therapies.