HEALTH AND SOCIOECONOMIC CONSEQUENCES OF NSBRI

说明： 此修订后的RO1应用程序的主要目标是确定 非特定建筑相关疾病的社会经济后果(或 在被诊断为这种流行疾病的工人中出现了病态建筑综合症。更多 超过一半的美国劳动力现在受雇于室内非工业 环境。各种症状和疾病的报告越来越多地在 这样的非工业室内环境。NSBRI指的是公共的非特定 通常与特定建筑有关的紊乱。虽然 客观的生理异常一般不被注意到，NSBRI可以 非常令人不快，也是导致残疾和损失工作时间的重要原因。 尽管如此，NSBRI几乎没有得到临床和临床的科学关注 从经济角度来看。在建立以下方面进展甚微：1) 诊断标准，2)NSBRI的自然病史或临床病程，3) 这一共同和重要职业的社会和经济后果 健康问题，或4)不良后果的预测因素。我们的具体目标 目标1 A)使用几个不同的病例识别和分类NSBRI病例 NSBRI的定义。目标1 B)确定不同的 病例定义和各种结果变量。目标2 A)描述 确诊后NSBRI的自然病史。目标2B)确定哪台主机 因素(即年龄、婚姻状况、初始症状)和工作场所因素 (例如，工作压力、工作环境)与疾病进展和 严肃性。目标3A)确定NSBRI对社会经济成果的影响 (即工作残疾、就业状况、财务状况)。目标3 B)确定 哪些宿主因素和工作场所因素与更不利的 社会经济结果。总体研究设计将是一次回顾。 青年会75例NSBRI患者的纵向随访研究 1994年至1999年就诊。一组相似的75名肌肉骨骼患者 年龄、性别和诊断年份相匹配的人将作为对照 社会经济分析。电话采访将评估症状、一般健康状况、 诊断后的功能状态、残疾、压力和社会经济状况 NSBRI的。这项研究应该确定诊断标准，增加我们的 对NSBRI的自然历史和社会经济后果的理解， 以及确定与更糟糕的结果相关的风险因素。这 信息对于制定干预措施以预防和/或 改善NSBRI的不良后果。

DESCRIPTION: The primary goal of this revised RO1 application is to determine the health and socioeconomic consequences of nonspecific building-related illness (NSBRI) (or sick building syndome) in workers diagnosed with this prevalent disorder. More than half of the U.S. workforce is now employed in indoor nonindustrial environments. Various symptoms and illnesses have increasingly been reported in such nonindustrial indoor environments. NSBRI refers to a common nonspecific disorder which is usually associated with a particular building. Although objective physiologic abnormalities are generally not noted, NSBRI can be extremely unpleasant and an important cause of disability and lost work time. Despite this, NSBRI has received scant scientific attention from a clinical and economic perspective. Little progress has been made in establishing: 1) diagnostic criteria, 2) the natural history or clinical course of NSBRI, 3) the social and economic consequences of this common and important occupational health problem, or 4) the predictors of adverse outcomes. Our Specific Aims are: Aim 1 A) Identify and classify NSBRI cases using several different case definitions of NSBRI. Aim 1 B) Determine associations between the different case definitions and the various outcome variables. Aim 2 A) Characterize the natural history of NSBRI following diagnosis. Aim 2 B) Determine which host factors (i.e. age, marital status, initial symptoms) and workplace factors (i.e. job stress, work environment) are associated with disease progression and severity. Aim 3 A) Determine the effect of NSBRI on socioeconomic outcomes (i.e. work-disability, employment status, financial status). Aim 3 B) Determine which host factors and workplace factors are associated with more adverse socioeconomic outcomes. The overall study design will be a retrospective longitudinal follow-up study of 75 patients diagnosed with NSBRI at the YOEMP Clinic from 1994 to 1999. A similar group of 75 musculoskeletal patients matched on age, gender and year of diagnosis will be used as scontrols for the socioeconomic analysis. Phone interviews will assess symptoms, general health, functional status, disability, stress, and socioeconomic status since diagnosis of NSBRI. This study should identify diagnostic criteria, increase our understanding of the natural history and socioeconomic consequences of NSBRI, as well as identify risk factors associated with worse outcomes. This information is critical for the development of interventions to prevent and/or ameliorate the adverse consequences of NSBRI.