Catalytic Reductive N Alkylation of Amines Using Carboxylic Acids

这项合作将提供一种强大的新方法，用于胺的N-烷基化反应，使用容易获得的和工作台稳定的羧酸代替醛。该项目将提供有机硅化学和均相金属催化反应的设计和优化方面的优秀背景。最后，原料药的合成将提供良好的训练，在建设药学相关的目标分子。目的：开发工艺友好的催化还原胺化反应的羧酸和胺，以提供更高的烷基化胺。这将通过硅烷介导的直接酰胺化反应与衍生酰胺的催化还原的组合来实现（方案1）。这项合作与EPSRC的“催化”和“合成有机化学”研究领域保持一致。催化领域已被EPSRC指定为增长领域，该项目显然福尔斯EPSRC定义的“新型或改进催化剂的制备和新催化工艺的开发”。该项目将为合成胺提供新的催化方法，这是至关重要的。

This collaboration will deliver a powerful new method for N-alkylation reactions of amines using readily available and bench stable carboxylic acids in place of aldehydes. The project will provide an excellent background in organosilicon chemistry and in the design and optimisation of homogeneous metal-catalysed reactions. Finally, the synthesis of APIs will provide excellent training in the construction of pharmaceutically relevant target molecules.AIM: To develop process friendly catalytic reductive amination reactions of carboxylic acids and amines to afford higher alkylated amines. This will be achieved via the combination of a silane-mediated direct amidation reaction with catalytic reduction of the derived amide (Scheme 1).ALIGNMENT WITH EPSRC RESEARCH AREAS. This collaboration is aligned with the EPSRC research areas of "catalysis" and "synthetic organic chemistry". The area of catalysis has been designated as a growth area by the EPSRC and this project clearly falls within the EPSRC definition of "preparation of novel or improved catalysts and the development of new catalytic processes". The project will deliver new catalytic methods for the synthesis of amines, which are of fundamental importance.