Effectiveness and cost-effectiveness of systematic screening for Lynch Syndrome (LS) in Australia

林奇综合征（LS）是一种遗传性疾病，使人们患一系列癌症的风险增加。我们将使用一个详细的模拟模型来评估测试新的结直肠癌，子宫内膜癌和卵巢癌LS病例的潜在健康益处，以及这是否具有成本效益。目的是确定LS相关的癌症病例，因此可以为家庭成员提供LS检测，并为发现LS的个人提供密切观察/预防性手术。

Lynch syndrome (LS) is an inherited condition that puts people at an increased risk of developing a range of cancers. We will use a detailed simulation model to evaluate the potential health benefits of testing new cases of colorectal, endometrial and ovarian cancers for LS, and whether this would be cost-effective. The aim is to identify LS-related cancer cases, so family members can be offered LS testing, and individuals found to have LS can be offered close observation/preventative surgery.