Enhancing Effectiveness of a Dissonance-Based Obesity Prevention Program

提高基于失调的肥胖预防计划的有效性

• 批准号: 10849600
• 负责人: ERIC M STICE
• 金额: $ 17.05万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10849600
• 关键词: 20 year old; Adolescence; Adolescent; Attention; Attitude; Behavior; Body mass index; Calories; Computers; Dietary intake; Education; Effectiveness; Exercise; Exhibits; Fatty acid glycerol esters; Female; Food; Functional Magnetic Resonance Imaging; Future; Health; Image; In complete remission; Intervention; Life Style; Mediating; Morbidity - disease rate; Obesity; Outcome Assessment; Overweight; Participant; Prevalence; Prevention; Prevention program; Randomized; Rewards; Risk; Signal Transduction; Testing; Thinness; Training; Unhealthy Diet; Weight Gain; Youth; attentional bias; cohesion; cost; energy balance; excessive weight gain; executive function; follow-up; good diet; health goals; improved; male; mortality; novel; obesity prevention; pilot trial; prevent; programs; randomized trial; response; sedentary lifestyle; sex; visual search; weight gain prevention; willingness to pay

Contact PD/PI: Stice, Eric ABSTRACT Prevention is key for combating obesity, but few programs have prevented future increases in BMI and onset of overweight/obesity, particularly during late adolescence when youth often assume responsibility for dietary intake and exercise choices. One exception is a brief 6-hr dissonance-based program (Project Health) wherein participants make small lasting incremental lifestyle changes to dietary intake and exercise to reach energy balance, and discuss costs of obesity, an unhealthy diet, and sedentary behavior, and benefits of leanness, a healthy diet, and exercise, which prompts them to align their attitudes with their publically displayed behavior. These activities promote internalization of health goals and executive control over lifestyle behaviors. Late adolescents randomized to Project Health showed less increases in BMI and a 41% and 43% reduction in overweight/obesity onset over 2-yr follow-up compared to a version of the program lacking dissonance- induction activities and an obesity education condition. Project Health appears to be the first program to produce these key obesity prevention effects relative to an alternative intervention, but it is critical to increase effects. A dissonance-based prevention program was more effective when implemented in single- versus mixed-sex groups, theoretically because it promoted greater participation in dissonance-inducing discussions. Aim 1a is to test whether the weight gain prevention effects will be larger when Project Health is implemented in single-sex groups; we will randomize 450 17-20 year olds to complete Project Health in female, male, or mixed-sex groups, assessing outcomes at pretest, posttest, and 6, 12, 24, and 36-month follow-ups. Aim 1b is to test whether greater participation in dissonance-inducing discussions and group cohesion mediate the effect of condition on any superior weight gain prevention effects. Adolescents who show greater fMRI-assessed reward and attention region responsivity to food images exhibit elevated future weight gain, implying that reducing this responsivity may reduce future weight gain. In a pilot trial, late adolescents who completed go/no- go, stop-signal, and respond-signal computer training in which they repeatedly inhibit responses to high-calorie foods and respond to low-calorie foods, and dot-probe and visual-search computer tasks that train attention away from high-calorie foods and to low-calorie foods, showed a greater reduction in reward and attention region responsivity to, palatability rating of, and willingness to pay for, high-calorie foods, suggesting reduced valuation and attentional bias, as well as greater fat loss over 1-yr follow-up versus controls who completed the training with non-food images. Aim 2a is to test whether adding food response and attention training to Project Health will produce larger weight gain prevention effects. Participants in the 3 conditions will be randomized to complete response and attention training for 25-mins after each of the 6-sessions with either food or non-food images. Aim 2b is to test whether reduced palatability ratings of, willingness to pay, and attentional bias for high-calorie foods mediate the effect of training condition on any superior weight gain prevention effects. Project Summary/Abstract Page 6

联系PD/PI: Stice， Eric

项目成果

Enhancing Efficacy of a Brief Obesity and Eating Disorder Prevention Program: Long-Term Results from an Experimental Therapeutics Trial.

• DOI: 10.3390/nu15041008
• 发表时间: 2023-02-17
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Stice E;Rohde P;Butryn ML;Desjardins C;Shaw H
• 通讯作者: Shaw H

Enhancing efficacy of a dissonance-based obesity and eating disorder prevention program: Experimental therapeutics.

• DOI: 10.1037/ccp0000682
• 发表时间: 2021-10
• 期刊: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
• 影响因子: 5.9
• 作者: Stice, Eric;Rohde, Paul;Gau, Jeff M;Butryn, Meghan L;Shaw, Heather;Cloud, Kasie;D'Adamo, Laura
• 通讯作者: D'Adamo, Laura