Chemical Characterisation of New Psychoactive Substances and Evaluating their implications on Human Health and Wellbeing

秘密药物化合物的化学特征主要在两种情况下使用，一是用于法医案件对案件的比较，二是作为更广泛的国家和国际警察和执法情报倡议的一部分。目前的许多研究侧重于分析安非他明、甲基安非他明和摇头丸等合成化合物中的有机杂质，或通过分析和解释半合成化合物与海洛因和可卡因非法混合物中主要存在的天然生物碱的混合物的杂质分布。关于新的精神活性物质(NPS)，还没有开展过这样的工作。其次，尚未对不同配方(粉剂、片剂等)进行针对性的免疫毒性研究。苯丙胺类兴奋剂(安非他明类兴奋剂)或NPS制剂。坊间证据表明，由于配方改变而可能产生的多态现象可能会造成特定的和潜在的严重健康影响，包括增加发病风险。目前，人们对这些物质的短期或长期健康影响了解甚少。这个项目的目标有两个。我们将寻求合成和创建具有化学特征的NPS和ATS化合物的基本事实数据库。这将帮助国家和国际执法机构确定这些材料，为情报主导的毒品破坏战略提供一个框架。其次，该项目将产生进行适当神经毒性研究所需的NPS和ATS标准，为了解与摄入这些物质有关的短期、中期和长期健康影响奠定基础。据估计，英国每周有60万名NPS用户，这将是第一项评估滥用此类材料的医学影响的全面研究。

Chemical characterisation of clandestine drug compounds is used primarily in two circumstances, in forensic case to case comparisons and as part of wider national and international police and law enforcement intelligence initiatives. Much research currently focuses on the analysis of organic impurities in synthetically produced compounds such as amphetamine, methylamphetamine and ecstasy or through the analysis and interpretation of impurity profiles of a mixture of semi synthetic compounds and naturally occurring alkaloids which predominate in illicit mixtures of heroin and cocaine. No such work has been carried out on New Psychoactive Substances (NPS). Secondly, no targeted immunotoxicity research has been undertaken on different formulations (powders, tablets etc.) of amphetamine type stimulants (ATS) or NPS formulations. Anecdotal evidence suggests that polymorphisms which may be produced as a result of alteration in formulation may create specific and potentially severe health effects including increase risk of morbidity. There is currently little if any understanding of the short or long term health effects of these types of substances. The objectives of this project are twofold. We will seek to synthesise and create a ground truth data base of chemically characterised NPS and ATS compounds. This will aid National and International law enforcement agencies in the identification of these materials providing a framework for intelligence led drug disruption strategies. Secondly, this project will generate the NPS and ATS standards required to undertake the appropriate neurotoxicity studies creating the foundation for understanding the short, medium and long term health implications relating to the ingestion of these substances. With an estimated 600,000 users of NPS in the UK per week this will be the first comprehensive study assessing the medical implications of the abuse of such materials.