MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER

多功能关节炎和肌肉骨骼疾病中心 北卡罗来纳州查珀尔H大学。由学院特许 医学作为瑟斯顿关节炎研究中心，由一个 生物医学研究组成部分，教育，流行病学和健康 服务研究（E/E/HSR）组件，生物分子核心，数值 科学核心，和一个行政单位。正在进行和计划 生物医学研究部分的调查包括许多 与自身免疫、关节炎和肌肉骨骼疾病相关的问题： 遗传学，调节和识别元件的功能， 异常免疫反应;肽/MHC结构功能关系; 细胞因子和炎症反应基因的诱导和调节; T细胞受体和B细胞IG基因库及其在免疫调节中的作用 自身免疫; T细胞活化和信号转导;分子 自身抗体形成的遗传学;自身抗体对 疾病发病机制;免疫抑制;自身免疫激发剂; 实验性关节炎炎症及其治疗;生物化学和 软骨细胞生物学;机械性关节损伤的病理生理学， 它与骨关节炎的关系;关节炎的临床研究， 骨质疏松症和全身性结缔组织疾病; 痛苦提出了三个开发和可行性项目。"机制 抗nRNP/Sm自身抗体扩散";" β 2GPI在 细胞凋亡";和"用饮食甘氨酸预防关节炎"。一 生物分子核心提供：血清学和临床数据库和细胞 库;流式细胞术;和近交系小鼠集落;和生物分子成像 设施。E/E/HSR部分的研究主题包括：1）研究 旨在增加我们对人们如何适应和应对 关节炎; 2）开发或验证相关测量程序 3）旨在描述关节炎的流行病学研究 特定关节炎的患病率、相关因素和潜在决定因素 疾病（目前为骨关节炎和SLE）或其后遗症; 4） 预防战略; 5）结果研究;和6）教育方案， 医生和其他卫生专业人员谁治疗病人 关节炎在E/E/HSR部分中提出了四个项目： 和进展的膝关节和髋关节骨关节炎在约翰斯顿县，北卡罗来纳州"; "患有关节炎的人与其配偶之间的情绪传染"; "类风湿性关节炎的自我管理、教育和结果"; 类风湿性关节炎患者骨质疏松的预防 口服糖皮质激素治疗"。数字科学核心提供： 方法学咨询和审查;发展和维持 患者数据库;数据录入和管理;生物统计咨询; 教育和计算机技术。

The Multipurpose Arthritis & Musculoskeletal Diseases Center at the University of North Carolina at Chapel H. chartered by the School of Medicine as the Thurston Arthritis Research Center, consists of a Biomedical Research Component, an Education, Epidemiology, & Health Services Research (E/E/HSR) Component, a Biomolecular Core, a Numerical Sciences Core, and an Administrative Unit. Ongoing and planned investigation in the Biomedical Research component encompasses many of the issues relevant to autoimmunity, arthritis, and musculoskeletal disease: genetics, regulation, and function of recognition elements in normal and abnormal immune responses; peptide/MHC structure function relationships; induction and regulation of cytokine and inflammatory responses genes; the repertoire of T cell receptor and B cell Ig genes and their role in autoimmunity; T cell activation and signal transduction; molecular genetics of autoantibody formation; contribution of autoantibodies to disease pathogenesis; immunosuppression; inciting agents in autoimmunity; inflammation in experimental arthritis and its therapy; biochemistry and cell biology of cartilage; pathophysiology of mechanical joint injury and its relationship to osteoarthritis; clinical investigation of arthritis, osteoporosis, and systemic connective tissue diseases; and mechanisms of pain. Three Development & Feasibility projects are proposed. "Mechanisms of anti-nRNP/Sm autoantibody spreading"; "The role of beta2GPI in apoptosis"; and "Prevention of Arthritis with Dietary Glycine". A Biomolecular Core provides: serological and clinical databases and a cell bank; flow cytometry; and inbred mouse colony; and a biomolecular imaging facility. Research themes in the E/E/HSR Component include: 1) studies aimed at increasing our understanding of how people adapt to and cope with arthritis; 2) development or validation of measurement procedures related to arthritis; 3) epidemiological studies aimed at describing the prevalence, correlates, and potential determinants of specific arthritic disorders (currently osteoarthritis and SLE) or their sequelae; 4) prevention strategies; 5) outcomes research; and 6) education programs for physicians and other health professionals who treat patients with arthritis. Four projects are proposed in the E/E/HSR Component: "Incidence and progression of knee and hip osteoarthritis in Johnston County, NC"; "Emotional contagion between people having arthritis and their spouses"; "Self-management, education and outcomes in rheumatoid arthritis"; and "Osteoporosis prevention among women with rheumatoid arthritis receiving oral glucocorticoid therapy". A Numerical Sciences Core provides: methodological consultation and review; development and maintenance of patient databases; data entry and management; biostatistical consultation; education; and computer technology.