Sensory experience and pre-configured networks in developing neural circuits for navigation'

这个项目将研究海马体空间神经地图的出生后发展，测试感觉经验和经验独立的预先配置的网络在导航神经回路组装中的作用。该项目将利用两项最近可用的技术：1)无线技术将被用于在自然环境中进行神经记录，研究感觉经验在发育中的作用；2)纵向双光子成像将被用于跟踪海马网在显示空间调节之前和之后的活动，测试是否存在经验无关的活动模式。

This project will investigate the post-natal development of the neural map of space in the hippocampus, testing the roles of sensory experience and experience-independent, pre-configured networks in the assembly of neural circuits for navigation. The project will make use of two recently available technologies: 1) wireless technology will be used to conduct neural recordings in natural environments, investigating the role of sensory experience in development, 2) longitudinal 2-photon imaging will be used to track the activity of hippocampal networks before and after they display spatial tuning, testing for the presence of experience independent activity patterns.