MICHIGAN PREVENTION RESEARCH CENTER

这项为密歇根预防研究中心提出的竞争性更新提案代表了一项长期协调研究计划的下一步，该计划旨在预防心理脆弱的个人和经历工作转变和经济压力的家庭的情绪和行为障碍。我们建议继续密歇根预防研究中心的预防研究项目，将新的重点放在降低抑郁症及其复发、相关残疾和其他共发疾病的风险上。此外，我们建议将我们的重点从失业问题扩大到更广泛的弱势个人和处于危险中的家庭。为了实现这一目标，我们建议继续将密歇根预防研究中心（MPRC）作为预防研究的国家资源，提供科学基础设施，进行随机对照现场试验，测试预防项目的功效、有效性和成本效益。该计划将通过实施四个相互关联的具体目标来实施，每个目标都有一个核心。这些核心旨在为以下方面提供高质量的科学基础设施：1)对表现出各种精神脆弱迹象并正在应对经济困难压力的高风险个人和家庭进行预防性干预措施的有效性试验；2)实施试验，以测试社区和服务系统中先前证明的预防性干预措施的有效性和成本效益；3)支持国家在测量方法方面取得进展的能力。为预防试验提供分析和数据管理，为全国的MPRC研究人员和预防科学家提供服务；4)为研究规划、社区合作和指导提供基础设施。

This competing renewal proposal for the Michigan Prevention Research Center represents the next step in a long term coordinated program of research on the prevention of emotional and behavioral disorders in psychologically vulnerable individuals and families experiencing work transitions and economic stress. We propose to continue the program of prevention research of the Michigan Prevention Research Center with a new expanded emphasis on the reduction of risks for depression and its recurrence and associated disability and other co-occurring illnesses. In addition, we propose to expand our focus from job loss to include a wider range of vulnerable individuals and families who are at risk. In order to accomplish this, we propose to continue the Michigan Prevention Research Center (MPRC) as a national resource for prevention research providing scientific infrastructure to conduct randomized controlled field trials testing the efficacy, effectiveness and cost effectiveness of preventive programs. The program will be carried out by implementing four interlocking specific aims, each represented by a core. The cores are designed to provide high quality scientific infrastructure for: 1) conducting efficacy trials of preventive interventions with high risk individuals and families whose members show various signs of psychiatric vulnerability and who are coping with the stresses of economic hardship, 2) implementing trials to test the effectiveness and cost effectiveness of previously proven preventive interventions in communities and service systems, 3) supporting a national capacity for methodological advances in measurement, analysis and data management for preventive trials, serving both MPRC researchers and prevention scientists nationwide, and 4) providing the infrastructure for research planning, community collaboration and mentoring.