CORE--CLINICAL AND MOLECULAR EPIDEMIOLOGY

该中心将提供全面的临床和分子流行病学 支持本计划项目的相关组成部分。 核心将 确定并招募所有符合条件的UTMDACC患者， 黑色素瘤皮肤癌，形成一个病人池，从这些病例将 根据具体的资格标准为每个项目选定。 将提供详细的临床和流行病学数据以及血液样本， 收集所有患者。 一种新的分子成分将研究p53， 所有可用肿瘤标本中的ras突变。 此外，对于项目 3（Wei博士，皮肤癌中的DNA修复和染色体不稳定性）300 将确定非癌症对照;对于项目5（Lippman博士， 侵袭性皮肤癌治疗的生物学方法）数据将 收集的生活质量部分。 这一核心也将是 负责数据质量、管理和检索。 数据将 保持在一个最新的，用户友好的，易于访问的数据库 以促进所有项目和核心数据的整合。

This core will provide comprehensive clinical and molecular epidemiologic support to the relevant components of this Program Project. This core will ascertain and enroll all eligible UTMDACC patients with biopsy-proven non- melanoma skin cancer to form a pool of patients from which cases will be selected for each project according to the specific eligibility criteria. Detailed clinical and epidemiologic data and a blood sample will be collected for all patients. A new molecular component will study p53 and ras mutations in all available tumor specimens. In addition, for Project 3 (Dr. Wei, DNA repair and chromosomal instability in skin cancers) 300 non-cancer controls will be identified; and for Project 5 (Dr. Lippman, Biologic approach to therapy of aggressive skin cancer) data will be collected for the Quality of life component. This core will also be responsible for data quality, management, and retrieval. Data will be maintained in an up-to-date, user friendly, and easily accessible database to facilitate the integration of data from all projects and cores.